Palinurin | 71947-64-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Palinurin
• 英文别名: 2(5H)-Furanone, 5-((2E,6S,7E,9E)-13-(3-furanyl)-2,6,10-trimethyl-2,7,9-tridecatrienyl)-4-hydroxy-3-methyl-, (5R)-；(2R)-2-[(2E,6S,7E,9E)-13-(furan-3-yl)-2,6,10-trimethyltrideca-2,7,9-trienyl]-3-hydroxy-4-methyl-2H-furan-5-one
• CAS: 71947-64-3
• 化学式: C₂₅H₃₄O₄
• 分子量: 398.543
• InChiKey: UXFNAATUJSSAHF-KCWPHIDLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  C.I.酸性橙108 、 Palinurin 在 fungus Cunninghamella sp. NRRL 5695 作用下， 反应 336.0h， 以4.8 mg的产率得到palinurine A
  参考文献：
  名称：

  The Biocatalytic Transformation of Furan to Amide in the Bioactive Marine Natural Product Palinurin

  摘要：

  DOI：

  10.1021/jo990539j

文献信息

• Gsk-3 inhibitors isolated from marine organisms
  申请人：Gordillo Alonso Diana

  公开号：US20070088080A1

  公开（公告）日：2007-04-19

  The present invention provides the use of a compound of formula (I); wherein: n is 0, 1, 2, or 3, the bonds shown with the dashed lines are saturated, or unsaturated with one or more double bonds; R, and R′are independently selected from hydrogen, alkyl, aryl, —OH, —OR″ —SH, —SR″—NH, —NHR″, ═O, ═NH, ═NR″; R″ is independently selected from alkyl, aryl, in the preparation of a medicament for the treatment of a disease requiring a GSK-3 inhibitor. Also provided is a compound of formula (II); wherein n is 0, 1, 2, or 3 the bonds shown with the dashed lines are saturated, or unsaturated with one or more double bonds. Also provided are methods of treating chronic neurodegenerative conditions.
• VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS
  申请人：Frequency Therapeutics, Inc.

  公开号：US20220133740A1

  公开（公告）日：2022-05-05

  The present invention provides methods for treating diseases and disorders of the ear with valproic acid compounds and Wnt agonists. The present invention further provides kits for the same.
• [EN] METHOD FOR PREPARATION OF A FURANOSESTERPENE OF MARINE ORIGIN<br/>[ES] PROCEDIMIENTO DE PREPARACIÓN DE UN FURANOSESTERPENO DE ORIGEN MARINO<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN FURANOSESTERPÈNE D'ORIGINE MARINE
  申请人：NEUROPHARMA SA

  公开号：WO2008116948A1

  公开（公告）日：2008-10-02

  [EN] The present invention concerns a method for synthesising, from commercial reagents of palinurina, a furanosesterpene of marine origin having various biological activities, in particular the kinase inhibitory activity thereof, for which reason it should have uses in treating certain pathologies, such as Alzheimer's disease.
  [FR] La présente invention concerne un procédé destiné à la synthèse, à partir de réactifs commerciaux, de palinurine, un furanosesterpène d'origine marine possédant diverses activités biologique, parmi lesquelles ressort son activité inhibitrice des kinases, la palinurine présentant ainsi un grand intérêt pour le traitement de certaines pathologiques, telles que la maladie d'Alzheimer.
  [ES] La presente invención está relacionada con un procedimiento de síntesis a partir de reactivos comerciales de la palinurina, un furanosesterpeno de origen marino que posee diversas actividades biológicas, entre las que destaca su actividad inhibitoria de quinasas, por lo que sería de gran interés para el tratamiento de ciertas patologías, tales como la enfermedad de Alzheimer.
• The Biocatalytic Transformation of Furan to Amide in the Bioactive Marine Natural Product Palinurin
  作者：Khalid A. El Sayed、Alejandro M. S. Mayer、Michelle Kelly、Mark T. Hamann

  DOI：10.1021/jo990539j

  日期：1999.12.1