硝基苄醇丙二酸单酯镁 | 83972-01-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 硝基苄醇丙二酸单酯镁
• 中文别名: 对硝基苄醇丙二酸单酯镁；对硝基苄醇丙二酸单酯镁盐
• 英文名称: magnesium mono-p-nitrobenzyl malonate
• 英文别名: magnesium;3-[(4-nitrophenyl)methoxy]-3-oxopropanoate
• CAS: 83972-01-4
• 化学式: C₂₀H₁₆MgN₂O₁₂
• 分子量: 500.658
• InChiKey: WAFDWKYNSTVECG-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -0.82
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  225
• 氢给体数：
  0
• 氢受体数：
  12

安全信息

• 海关编码：
  2918990090

制备方法与用途

制备方法

美罗培南医药中间体的制备方法。

用途简介

暂无相关信息。

反应信息

• 作为反应物：
  描述：

  (3S)-3-[(1R)-1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-[(2R)-1-imidazol-1-yl-1-oxopropan-2-yl]azetidin-2-one 、 硝基苄醇丙二酸单酯镁 以83%的产率得到
  参考文献：
  名称：

  DEZIEL, ROBERT;FAVREAU, DENIS, TETRAHEDRON LETT., 30,(1989) N1, C. 1345-1348

  摘要：

  DOI：

文献信息

• PROCESS FOR THE PREPARATION OF CARBAPENEM COMPOUNDS
  申请人：Tewari Neera

  公开号：US20110224426A1

  公开（公告）日：2011-09-15

  The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein P 1 is hydrogen or a carboxyl protecting group, P 3 is hydrogen or a hydroxyl protecting group, R 1 is C 1-3 alkyl, and A is selected from a group consisting of a) Formula (II), b) Formula (III), c) Formula (IV), d) Formula (V), e) Formula (VI), f) Formula (VII), wherein P 2 is hydrogen or an amino protecting group, R 2 and R 3 may be same or different and are hydrogen, C 1-5 alkyl, optionally substituted aryl, or optionally substituted heteroaryl, and X 1 is O or S, or its stereoisomers, or salts thereof.

  本发明涉及一种制备式(I)碳青霉烯化合物的工艺，其中P1为氢或羧酸保护基团，P3为氢或羟基保护基团，R1为C1-3烷基，A选自以下组：a)式(II)，b)式(III)，c)式(IV)，d)式(V)，e)式(VI)，f)式(VII)，其中P2为氢或氨基保护基团，R2和R3相同或不同，为氢，C1-5烷基，可选地取代的芳基或可选地取代的杂芳基，X1为O或S，或其立体异构体，或其盐。
• [EN] PROCESS FOR THE PREPARATION OF CARBAPENEM COMPOUNDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS CARBAPÉNÈMES
  申请人：RANBAXY LAB LTD

  公开号：WO2010013223A1

  公开（公告）日：2010-02-04

  The present invention relates to a process for the preparation of carbapenem compound of Formula (I), wherein P1 is hydrogen or a carboxyl protecting group, P3 is hydrogen or a hydroxyl protecting group, R1 is C1-3 alkyl, and A is selected from a group consisting of a) Formula (II), b) Formula (III), c) Formula (IV), d) Formula (V), e) Formula (VI), f) Formula (VII), wherein P2 is hydrogen or an amino protecting group, R2 and R3 may be same or different and are hydrogen, C1-5 alkyl, optionally substituted aryl, or optionally substituted heteroaryl, and X1 is O or S, or its stereoisomers, or salts thereof.

  本发明涉及一种制备式(I)碳青霉烯化合物的工艺，其中P1是氢或羧酸保护基，P3是氢或羟基保护基，R1是C1-3烷基，A选自以下一组：a)式(II)，b)式(III)，c)式(IV)，d)式(V)，e)式(VI)，f)式(VII)，其中P2是氢或氨基保护基，R2和R3可以相同或不同，为氢，C1-5烷基，可选地取代的芳基或可选地取代的杂芳基，X1是O或S，或其立体异构体，或其盐。
• 3(1-hydoxyethyl)azetidinone compounds and their production
  申请人：Sumitomo Pharmaceuticals Company, Limited

  公开号：US05134231A1

  公开（公告）日：1992-07-28

  An amino acid compound of the formula: ##STR1## wherein R is a lower alkyl group, R.sub.1 is a hydrogen atom or a protecting group for carboxyl, R.sub.2 is a hydrogen atom, a protecting group for amino, an optionally substituted allyl group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each a hydrogen atom, a lower alkyl group or an aryl group), a beta-hydroxyethyl group in which the hydroxyl group is optionally protected, a formylmethyl group in which the formyl group is optionally protected, a carboxymethyl group in which the carboxyl group is protected or a 2-furylmethyl group and X is an optionally protected carboxyl group, a hydroxymethyl group in which the hydroxyl group is optionally protected or a substituted mercaptomethyl group of the formula: --CH.sub.2 SR.sub.5 (wherein R.sub.5 is an aryl group or an ar(lower)alkyl group), which is a useful intermediate in the synthesis of 1-alkylcarbapenem compounds.

  化合物的氨基酸式：##STR1## 其中R是低碳基团，R.sub.1是羧基的保护基或氢原子，R.sub.2是氨基的保护基、可选取代的烯丙基式：##STR2##（其中R.sub.3和R.sub.4分别是氢原子、低碳基团或芳基团），β-羟乙基基团，其中羟基可以选择性保护，甲酰甲基基团，其中甲酰基可以选择性保护，羧甲基基团，其中羧基被保护或2-呋喃甲基基团，X是可选择性保护的羧基，羟甲基基团，其中羟基可以选择性保护，或取代的巯基甲基基团式：--CH.sub.2 SR.sub.5（其中R.sub.5是芳基团或芳(低)碳基团），该化合物是1-烷基卡巴冬烯类化合物合成中有用的中间体。
• Carbapenem compound, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US06174877B1

  公开（公告）日：2001-01-16

  A cephem compound of the formula: wherein R1 stands for an optionally substituted lower alkyl group, R2 stands for H or a lower alkyl group, R3 stands for H, an optionally substituted hydrocarbon group, cyano group, a lower alkyloxy group or a lower alkylthio group, and the ring A stands for an optionally substituted non-quaternarized nitrogen-containing heterocyclic ring, provided that, when A is unsubstituted 2-pyridyl group, R3 stands for a group other than hydrogen, or their esters or salts, has excellent antibacterial activities, oral absorbability and stability, and is useful as an antibacterial agent.

  一种头孢菌素类化合物，其化学式为：其中，R1代表可选取代的较低烷基基团，R2代表氢或较低烷基基团，R3代表氢、可选取代的碳氢基团、氰基、较低烷氧基或较低烷硫基团，环A代表可选取代的非季铵化含氮杂环，但当A为未取代的2-吡啶基时，R3代表非氢基团。该化合物及其酯类或盐类具有优异的抗菌活性、口服吸收性和稳定性，可作为抗菌剂使用。
• Novel 6-amido-1-methyl-2-(substituted-thio)-carbapenems
  申请人：Merck & Co., Inc.

  公开号：EP0350210A2

  公开（公告）日：1990-01-10

  New antibacterial 6-amido-1-methyl-2-(substituted-thio)-carbapenems and process for their synthesis involving new azetidinone intermediates.

  新型抗菌 6-氨基-1-甲基-2-(取代-硫代)-碳青霉烯类以及涉及新氮杂环丁酮中间体的合成工艺。