5,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraenoyl chloride | 83636-43-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5,9,13,17-Tetramethyloctadeca-4,8,12,16-tetraenoyl chloride
• CAS: 83636-43-5
• 化学式: C₂₂H₃₅ClO
• 分子量: 351.0
• InChiKey: JIJJYOGUEXXMPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  24
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Geranylgeranylacetamide compounds having a piperazine ring, salts thereof, process for preparation thereof, pharmaceutical compositions containing said compounds, and method of treating ulcers in mammals
  申请人：Nihon Iyakuhin Kogyo Co., Ltd.

  公开号：EP0096393A1

  公开（公告）日：1983-12-21

  A geranylgeranylacetamide compound having a piperazine ring represented by the following formula (1) wherein R represents a member selected from the class consisting of a hydrogen atom, C1-C5 alkyl groups which are unsubstituted or mono-substituted by a halogen atom, C2-C5 alkenyl groups and C7-C8 aralkyl groups, R, represents a C1-C3 alkyl group, and n represents 0, 1 or 2, and a pharmaceutically acceptable acid addition salt thereof. The aforesaid compound can be prepared by reacting geranylgeranylacetic acid or its reactive derivative with a piperazine compound, and therafter, if desired, transforming the free geranylgeranylacetamide compound thus obtained into its pharmaceutically acceptable acid addition salt. A phamaceu- tical composition containing said compound exhibits anti- ulcerogenic activity, particularly excellent antipeptic ulcerogenic activity, and is useful an agent for treating ulcers.

  一种具有下式（1）所代表的哌嗪环的香叶基乙酰胺化合物 其中 R 代表选自氢原子、未被卤素原子取代或被卤素原子单取代的 C1-C5 烷基、C2-C5 烯基和 C7-C8 芳基所组成的类别中的一个成员，R 代表 C1-C3 烷基，n 代表 0、1 或 2，以及其药学上可接受的酸加成盐。上述化合物可通过香叶基乙酸或其活性衍生物与哌嗪化合物反应制备，然后，如果需要，将由此获得的游离香叶基乙酰胺化合物转化为其药学上可接受的酸加成盐。含有上述化合物的医药组合物具有抗溃疡活性，尤其是优异的抗消化性溃疡活性，是治疗溃疡的有效药物。
• US4521417A
  申请人：——

  公开号：US4521417A

  公开（公告）日：1985-06-04