acridine-9-carbaldehyde-oxime | 112032-33-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: acridine-9-carbaldehyde-oxime
• 英文别名: Acridin-9-carbaldehyd-oxim；(NE)-N-(acridin-9-ylmethylidene)hydroxylamine
• CAS: 112032-33-4
• 化学式: C₁₄H₁₀N₂O
• 分子量: 222.246
• InChiKey: YHYQDUSLQTZHDY-OQLLNIDSSA-N

物化性质

• 熔点：
  243-244 °C(Solv: methanol (67-56-1))
• 沸点：
  434.8±18.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  9-吖啶羧醛 在 甲醇 、 羟胺 作用下， 生成 acridine-9-carbaldehyde-oxime
  参考文献：
  名称：

  Kaufmann; Vallette, Chemische Berichte, 1912, vol. 45, p. 1742

  摘要：

  DOI：

文献信息

• [EN] OXAZA HETEROCYCLIC COMPOUNDS FOR PHOTOTHERAPY<br/>[FR] COMPOSÉS OXAZA HÉTÉROCYCLIQUES POUR PHOTOTHÉRAPIE
  申请人：MALLINCKRODT INC

  公开号：WO2010132547A2

  公开（公告）日：2010-11-18

  The invention relates generally to optical agents, including phototherapeutic agents, for biomedical applications, including phototherapy. The invention includes optical agents, and related therapeutic methods, comprising oxaza compounds, including 1,2 oxaza heterocyclic compounds, having a photolabile N-O bond directly or indirectly linked to at least one carbocyclic aromatic and/or heterocyclic aromatic group. In some embodiments, for example, the invention provides oxaza compounds, such as oxazolines and isoxazolidines, for phototherapeutic methods having a photolabile N-O bond that undergoes photoactivated cleavage to produce reactive species, such as radicals, ions, etc., that achieve a desired therapeutic effect, such as selective and/or localized tissue damage and/or cell death.