1-(4-Azidophenyl)propan-1-one | 1363415-62-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Azidophenyl)propan-1-one
• CAS: 1363415-62-6
• 化学式: C₉H₉N₃O
• 分子量: 175.19
• InChiKey: UMMWWSVQPIWTRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-azido-N-cyclohexylbenzamide 、 diethylzinc 在 2-氟吡啶 、 三氟甲磺酸酐 、 盐酸 、 水 作用下， 以 二氯甲烷 、 四氢呋喃 为溶剂， 反应 2.0h， 以80%的产率得到1-(4-Azidophenyl)propan-1-one
  参考文献：
  名称：

  通过将有机金属试剂加入仲酰胺化学选择性合成酮和酮亚胺

  摘要：

  高效和选择性转化的发展在合成化学中至关重要，因为它为复杂分子的全合成开辟了新的可能性。将此类反应应用于酮的合成非常重要，因为该基序可作为合成众多有机功能的手柄。在这种情况下，我们报告了一种基于仲酰胺活化/加成序列的通用化学选择性方法，允许控制分离结构不同的酮和酮亚胺。发现高度亲电子的亚胺酰基三氟甲磺酸酯中间体的产生在观察到的异常官能团耐受性中起关键作用，允许将现成的格氏试剂和二有机锌试剂轻松添加到酰胺中，避免常见的过度加成或还原副反应。该方法已应用于抗肿瘤剂 Bexarotene 类似物的正式合成，以及在一锅法中快速有效地合成不对称二酮。

  DOI：

  10.1038/nchem.1268

文献信息

• POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF
  申请人：Kopecková Pavla

  公开号：US20130156722A1

  公开（公告）日：2013-06-20

  Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates.

  本文描述了一种可生物降解的药物传递共轭物，用于有效地将生物活性物质传递给受试者。药物传递共轭物包括水溶性高分子量线性可生物降解聚合物骨架，该骨架包括通过第一（主链）可断裂连接剂相互连接的多个线性水溶性聚合物段，其中生物活性物质与至少一个水溶性聚合物段，至少一个可断裂连接剂或其组合共价键合。与先前的传递共轭物相比，这些共轭物具有许多优点。本文还描述了制备和使用这些共轭物的方法。
• Benzimidazole derivatives and their use as a medicament
  申请人：Poitout Lydie

  公开号：US20090170922A1

  公开（公告）日：2009-07-02

  A subject of the present application is new benzimidazole derivatives of formula in which A, Y, R 1 , R 2 , R 3 and R 4 represent different variable groups. These products have an antagonist activity of GnRH (Gonadotropin-Releasing Hormone). The invention also relates to pharmaceutical compositions containing said products and their use for the preparation of a medicament.

  本申请的主题是公式中A、Y、R1、R2、R3和R4代表不同变量基团的新苯并咪唑衍生物。这些产物具有GnRH（促性腺激素释放激素）的拮抗活性。本发明还涉及含有所述产物的制药组合物及其用于制备药物的用途。
• SPHEROID COMPOSITE, SPHEROID-CONTAINING HYDROGEL AND PROCESSES FOR PRODUCTION OF SAME
  申请人：Otsuka Hidenori

  公开号：US20120015440A1

  公开（公告）日：2012-01-19

  A spheroid composite includes: a substrate including a cell-adhesive porous base material and plural hydrophilic regions and hydrophobic regions that are disposed on the porous base material and formed by curing a photosensitive composition, wherein the photosensitive composition includes a branched polyalkylene glycol derivative having three or more polyalkylene glycol groups, each having a polymerizable substituent at a terminal thereof, and a tri- or higher-valent linking group that binds to the polyalkylene glycol groups; and spheroids formed in the hydrophobic regions on the substrate, the plural spheroids having a uniform size. A spheroid-containing hydrogel, which includes a hydrogel and two or more spheroids having a uniform size with a diameter of from 70 μm to 400 μm that are disposed in the hydrogel in such a manner that the two or more spheroids do not contact each other, can favorably maintain the function of the plural spheroids contained within the hydrogel.
• COSMETIC METHOD FOR CONTROLLING ODORS
  申请人：L'OREAL

  公开号：US20170360678A1

  公开（公告）日：2017-12-21

  The invention relates to a cosmetic method for treating human body odors. Said method includes: (i) applying, to the skin, a composition containing a polymer (I): wherein R′ is, separately, H or an acetyl grouping or a —CO-L-X grouping, the polymer containing at least one R′═—CO-L-X grouping, L being a divalent hydrocarbon group containing 1 to 20 carbon atoms, X denoting a photoactive azide or diazirine group, and n ranging from 5 to 2000; then (ii) exposing the skin to visible light. The method used on the skin can also be used on materials for deodorizing malodorous environments such as shoe soles or clothing.
• US7244739B2
  申请人：——

  公开号：US7244739B2

  公开（公告）日：2007-07-17