4,6-二氟吲哚 | 199526-97-1

• 物质功能分类: 医药中间体 - 吲哚类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 4,6-二氟吲哚
• 英文名称: 4,6-difluoroindole
• 英文别名: 4,6-difluoro-1H-indole
• CAS: 199526-97-1
• 化学式: C₈H₅F₂N
• mdl: MFCD01075213
• 分子量: 153.131
• InChiKey: MHICCULQVCEWFH-UHFFFAOYSA-N

物化性质

• 沸点：
  253.2±20.0 °C(Predicted)
• 密度：
  1.388±0.06 g/cm3(Predicted)
• 溶解度：
  微溶(0.062g/L)(25°C)，计算值。

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  15.8
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  2-8℃

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
4,6-Difluoroindole
Product Name:
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
Wear protective gloves/protective clothing/eye protection/face protection
P280:
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P405: Store locked up

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Section 3. Composition/information on ingredients.
4,6-Difluoroindole
Ingredient name:
CAS number: 199526-97-1

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Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels, refrigerated.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C8H5F2N
Molecular weight: 153.1

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen fluoride.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4,6-二氟吲哚 在 盐酸 、 三乙基硅烷 、 三氟乙酸 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 生成 5-溴-4,6-二氟-1H-吲哚
  参考文献：
  名称：

  用于治疗糖尿病性肾病的AMPK激活剂合成的演变：从三个临床前候选药物到正在研究的新药PF-06409577

  摘要：

  吲哚羧酸1，2，和3是有效的5'-腺苷对于糖尿病性肾病的潜在治疗单磷酸活化蛋白激酶（AMPK）激活剂。化合物1 - 3分别缩放以用于临床前研究提供材料，和吲哚3被选择用于人类首创的临床试验，并按千克量定标。描述了这些AMPK激活剂的合成策略的进展，为有效的结构-活性关系生成选择了路线，然后针对更大的规模对其进行了改进。所开发的序列采用了中间体和API的实际分离方法，可重现的交叉偶联，水解和其他转化方法，并提高了安全性和纯度，从而生产了40–50 g的1和2和2.4 kg的3。观察到3的多个多晶型物，并确定了可重复形成适合临床发展的结晶物质的条件。

  DOI：

  10.1021/acs.oprd.8b00059
• 作为产物：
  描述：

  2,4-二氟苯甲醛 在 N-甲基吡咯烷酮 、 sodium hydroxide 、 sodium methylate 、 铜 作用下， 反应 16.5h， 生成 4,6-二氟吲哚
  参考文献：
  名称：

  Synthesis and structure of fluoroindole nucleosides

  摘要：

  化学修饰碱基常用于稳定核酸、研究核酸结构形成的驱动力以及调整 DNA 和 RNA 杂交条件。核苷类似物是研究氢键、碱基堆积和溶解这三种导致核酸稳定性的主要作用力的化学手段。为了更深入地了解这些相互作用对 RNA 稳定性的贡献，我们决定合成一些新型核酸类似物，用氟化吲哚取代核碱基。氟化吲哚可与氟化苯并咪唑进行比较，以确定氮在五元环系统中的作用。本文报告了氟吲哚核糖核苷的合成以及所有合成的氟吲哚核糖核苷的 X 射线晶体结构。这些化合物也可能成为多种具有生物活性的 RNA 类似物的构建基块。

  DOI：

  10.1139/v07-020

文献信息

• [EN] N-SUBSTITUTED INDOLE DERIVATIVES AS PGE2 RECEPTOR MODULATORS<br/>[FR] UTILISATION DE DÉRIVÉS D'INDOLE N-SUBSTITUÉS COMME MODULATEURS DES RÉCEPTEURS DES PGE2
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2017085198A1

  公开（公告）日：2017-05-26

  The present invention relates to derivativesof formula (I) wherein (R1)n, R2, R3, R4a, R4b, R5a, R5b and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.

  本发明涉及公式(I)的衍生物，其中(R1)n，R2，R3，R4a，R4b，R5a，R5b和Ar1如描述中所述，其制备方法，其药学上可接受的盐，以及作为药物的用途，含有一个或多个公式(I)化合物的药物组合物，特别是作为前列腺素2受体EP2和/或EP4的调节剂的用途。
• [EN] NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF<br/>[FR] NOUVEAUX ACTIVATEURS DE LA GUANYLATE CYCLASE SOLUBLE À DOUBLE MODE D'ACTION ET INHIBITEURS DE PHOSPHODIESTÉRASE ET LEURS UTILISATIONS
  申请人：TOPADUR PHARMA AG

  公开号：WO2021245192A1

  公开（公告）日：2021-12-09

  The present invention relates to compounds of formula (I), or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein said compound of formula (I) comprises at least one covalently bound -ONO2 or -ONO moiety and at most four covalently bound -ONO2 or -ONO moieties, and wherein AR, R1, X, R3 and R4 are as defined in claim 1; and pharmaceutical compositions thereof, and their use in methods of treating or preventing a disease alleviated by inhibition of PDE5 in a human or in a non-human mammal.

  本发明涉及式(I)的化合物，或其药学上可接受的盐、溶剂或水合物，其中所述式(I)的化合物至少包括一个共价结合的-ONO2或-ONO基团，最多包括四个共价结合的-ONO2或-ONO基团，其中AR、R1、X、R3和R4如权利要求1所定义；以及其药物组合物，以及它们在治疗或预防通过抑制人类或非人类哺乳动物中的PDE5而缓解的疾病的方法中的使用。
• [EN] (AZA)INDOLE-, BENZOTHIOPHENE-, AND BENZOFURAN-3-SULFONAMIDES<br/>[FR] (AZA)INDOLE, BENZOTHIOPHÈNE ET BENZOFURAN-3-SULFONAMIDES
  申请人：UCB PHARMA GMBH

  公开号：WO2018122232A1

  公开（公告）日：2018-07-05

  Disclosed are sulfonamide compounds with GPR17 modulating properties, which are useful for treating or preventing a variety of CNS and other diseases, in particular for preventing and treating myelinating diseases or disorders.

  揭示了具有GPR17调节特性的磺胺类化合物，可用于治疗或预防各种中枢神经系统和其他疾病，特别是用于预防和治疗髓鞘疾病或紊乱。
• Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents
  作者：Yuhong Yang、Yuanyuan Xu、Yuan Yue、Heng Wang、Yumeng Cui、Miaomiao Pan、Xi Zhang、Lin Zhang、Haitao Li、Min Xu、Yefeng Tang、Shawn Chen

  DOI：10.1021/acschembio.1c00394

  日期：2022.1.21

  Indolmycin (IND) is a microbial natural product that selectively inhibits bacterial tryptophanyl-tRNA synthetase (TrpRS). The tryptophan biosynthesis pathway was recently shown to be an important target for developing new antibacterial agents against Mycobacterium tuberculosis (Mtb). We investigated the antibacterial activity of IND against several mycobacterial model strains. A TrpRS biochemical assay

  吲哚霉素 (IND) 是一种微生物天然产物，可选择性抑制细菌色氨酸-tRNA 合成酶 (TrpRS)。色氨酸生物合成途径最近被证明是开发针对结核分枝杆菌(Mtb) 的新型抗菌剂的重要目标。我们研究了 IND 对几种分枝杆菌模型菌株的抗菌活性。开发了一种 TrpRS 生化试验来分析合成 IND 类似物的文库。4″-甲基化 IND 化合物 Y-13 显示出改善的抗 Mtb 活性，最小抑制浓度 (MIC) 为 1.88 μM (~0.5 μg/mL)。当在基因工程替代牛分枝杆菌中诱导 TrpRS 过表达时，MIC 显着增加卡介苗。Mtb TrpRS 与 IND 和 ATP 复合的共晶结构表明氨基酸袋处于 apo 蛋白的开放形式和与反应中间体的封闭复合物之间的状态。在基于全细胞的实验中，我们研究了 Y-13 与不同抗菌剂的组合效果。我们通过基因组测序评估了杀伤动力学、对 IND 的抗性频率以及 IND
• INDOLE AND INDAZOLE COMPOUNDS THAT ACTIVATE AMPK
  申请人：PFIZER INC.

  公开号：US20130267493A1

  公开（公告）日：2013-10-10

  The present invention relates to indole and indazole compounds of Formula (I) that activate 5′ adenosine monophosphate-activated protein kinase (AMPK). The invention also encompasses pharmaceutical compositions containing these compounds and methods for treating or preventing diseases, conditions, or disorders ameliorated by activation of AMPK.

  本发明涉及激活5'-腺苷单磷酸活化蛋白激酶（AMPK）的吲哚和吲唑化合物的化学式（I）。该发明还包括含有这些化合物的药物组合物以及治疗或预防通过激活AMPK改善的疾病、症状或疾病的方法。