(R)-2-Ethoxy-butane-1,4-diol | 869891-20-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-2-Ethoxy-butane-1,4-diol
• 英文别名: (2R)-2-ethoxybutane-1,4-diol
• CAS: 869891-20-3
• 化学式: C₆H₁₄O₃
• 分子量: 134.175
• InChiKey: IRZLMNRFLJUTJZ-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (R)-2-Ethoxy-butane-1,4-diol 在 palladium on activated charcoal 吡啶 、 sodium azide 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 100.0 ℃ 、7.3 MPa 条件下， 反应 9.5h， 生成 (R)-2-ethoxy-1,4-diaminobutane
  参考文献：
  名称：

  Synthesis and in vitro cytotoxicity of novel hydrophilic chiral 2-alkoxy-1,4-butanediamine platinum (II) complexes

  摘要：

  Twenty-six new hydrophilic chiral 2-alkoxy-1,4-butanediamine platinum (II) complexes having a seven-membered ring structure between a bidentate carrier ligand and a platinum atom have been synthesized and most of them were evaluated for their in vitro cytotoxicity toward A549 human non-small cell lung carcinoma and HCT-116 human colon cancer cell lines. The cytotoxicities of platinum complexes are related to the nature of the carrier ligand and leaving group. Complex 5'b, viz. cis-dichloro[(2R)ethoxy-1,4-butanediamine] platinum (11), exhibits the greatest potency among those 21 tested platinum complexes in both cell lines. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.025
• 作为产物：
  描述：

  ethyl ether d-malic acid diethyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 (R)-2-Ethoxy-butane-1,4-diol
  参考文献：
  名称：

  Synthesis and in vitro cytotoxicity of novel hydrophilic chiral 2-alkoxy-1,4-butanediamine platinum (II) complexes

  摘要：

  Twenty-six new hydrophilic chiral 2-alkoxy-1,4-butanediamine platinum (II) complexes having a seven-membered ring structure between a bidentate carrier ligand and a platinum atom have been synthesized and most of them were evaluated for their in vitro cytotoxicity toward A549 human non-small cell lung carcinoma and HCT-116 human colon cancer cell lines. The cytotoxicities of platinum complexes are related to the nature of the carrier ligand and leaving group. Complex 5'b, viz. cis-dichloro[(2R)ethoxy-1,4-butanediamine] platinum (11), exhibits the greatest potency among those 21 tested platinum complexes in both cell lines. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.08.025