安他唑啉甲烷磺酸盐 | 3131-32-6

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 安他唑啉甲烷磺酸盐
• 中文别名: 2-(N-苄基苯胺基甲基)-2-咪唑啉
• 英文名称: N-benzyl-N-(4,5-dihydro-1H-imidazol-1-ium-2-ylmethyl)aniline;methanesulfonate
• CAS: 3131-32-6
• 化学式: C18H23N3O3S
• 分子量: 361.5
• InChiKey: PIEHFGHAWYGNCY-UHFFFAOYSA-N

物化性质

• 熔点：
  168-169 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.83
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  97.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S26,S36
• 危险类别码：
  R20/21/22,R36/37/38
• 海关编码：
  2933290090

文献信息

• An otorhinological drug delivery device
  申请人：Schering Oy

  公开号：EP1438942A1

  公开（公告）日：2004-07-21

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的芯体，其中所述芯体由弹性体组合物制成，该弹性体组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元S原子上的3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧烷）基团）及其混合物组成的组。
• Otorhinological delivery device
  申请人：Haapakumpu Timo

  公开号：US20060067982A1

  公开（公告）日：2006-03-30

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的核心，其中所述核心由弹性体组合物制成，该组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元硅原子上的 3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧亚烷基）基团）及其混合物组成的组、以及包覆所述芯材的膜，所述膜由与所述芯材相同或不同的弹性体组合物制成，所述弹性体组合物选自聚二甲基硅氧烷、硅氧烷单元硅原子上附有 3,3,3-三氟丙基的硅氧烷基弹性体、聚环氧烷基硅氧烷基弹性体及其混合物组成的组。本发明的特征在于，药物活性剂选自抗过敏剂、抗炎剂、抗真菌剂、糖皮质激素及其混合物。
• US7294345B2
  申请人：——

  公开号：US7294345B2

  公开（公告）日：2007-11-13
• [EN] AN OTORHINOLOGICAL DELIVERY DEVICE<br/>[FR] DISPOSITIF DE DISTRIBUTION OTO-RHINOLOGIQUE
  申请人：SCHERING OY

  公开号：WO2004064912A1

  公开（公告）日：2004-08-05

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si­atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si­atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.