pent-4-en-1-yl 1-thio-β-D-maltoheptaoside | 1355163-91-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: pent-4-en-1-yl 1-thio-β-D-maltoheptaoside
• CAS: 1355163-91-5
• 化学式: C₄₇H₈₀O₃₅S
• 分子量: 1237.2
• InChiKey: GYZQWIDCLAVTFZ-JIFUCGGVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -13.57
• 重原子数：
  83.0
• 可旋转键数：
  24.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  565.05
• 氢给体数：
  22.0
• 氢受体数：
  36.0

反应信息

• 作为反应物：
  描述：

  pent-4-en-1-yl 1-thio-β-D-maltoheptaoside 、 2-naphthaldehyde di(i-butyl)acetal 在 D(+)-10-樟脑磺酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Synthetic studies of bi-fluorescence-labeled maltooligosaccharides as substrates for α-amylase on the basis of fluorescence resonance energy transfer (FRET)

  摘要：

  A series of bi-fluorescence-labeled maltooligosaccharides that lead to fluorescence resonance energy transfer (FRET) was systematically synthesized. Effective FRETs were observed with all of the synthesized probes. Digestion of probes having tetra-, quintet-, hexa- or hepta-saccharidic chain lengths with human saliva alpha-amylase resulted in disappearance of FRET when an excitation wavelength of at 290 nm was used followed by detection at ca. 520 nm due to emission from the dansyl moiety. However, continuous FRET was observed when probes having di- or trisaccharidic chain lengths were used as substrates. In addition to the substrate characteristics based on saccharidic chain length, the reaction rates of digestion for the substrates by amylase were different and also depended on their saccharidic chain length. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.065
• 作为产物：
  描述：

  pent-4-en-1-yl 2(VII),3(VII),4(VII),6(VII),2(VI),3(VI),6(VI),2(V),3(V),6(V),2(IV),3(IV),6(IV),2(III),3(III),6(III),2(II),3(II),6(II),2,3,6-docosa-O-acetyl-1-thio-β-maltoheptaoside 在 甲醇 、 sodium methylate 作用下， 以100%的产率得到pent-4-en-1-yl 1-thio-β-D-maltoheptaoside
  参考文献：
  名称：

  Synthetic studies of bi-fluorescence-labeled maltooligosaccharides as substrates for α-amylase on the basis of fluorescence resonance energy transfer (FRET)

  摘要：

  A series of bi-fluorescence-labeled maltooligosaccharides that lead to fluorescence resonance energy transfer (FRET) was systematically synthesized. Effective FRETs were observed with all of the synthesized probes. Digestion of probes having tetra-, quintet-, hexa- or hepta-saccharidic chain lengths with human saliva alpha-amylase resulted in disappearance of FRET when an excitation wavelength of at 290 nm was used followed by detection at ca. 520 nm due to emission from the dansyl moiety. However, continuous FRET was observed when probes having di- or trisaccharidic chain lengths were used as substrates. In addition to the substrate characteristics based on saccharidic chain length, the reaction rates of digestion for the substrates by amylase were different and also depended on their saccharidic chain length. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.065