3-(2-hexyloxy-ethoxy)-propylamine | 99990-68-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-hexyloxy-ethoxy)-propylamine
• 英文别名: 1-(3-Amino-propoxy)-2-hexyloxy-aethan；3-(2-Hexyloxy-aethoxy)-propylamin；3-(2-Hexoxyethoxy)propan-1-amine
• CAS: 99990-68-8
• 化学式: C₁₁H₂₅NO₂
• 分子量: 203.325
• InChiKey: OYSCBECQCMGRIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-hexyloxy-ethoxy)-propylamine 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 N,N'-Bis-[3-(2-hexyloxy-ethoxy)-propyl]-ethane-1,2-diamine
  参考文献：
  名称：

  Aldose epimerization by Ni(II): effect of ether-containing alkylenediamine ligands

  摘要：

  Several N-substituted ethylenediamine (en) Ni(II) derivatives containing ether linkages were prepared in order to study the effect of ligand structure on C-2 epimerization of aldohexoses. The reagent consisted of a Ni(II)-alkylenediamine derivative in methanol. The presence of ether linkages in the ligand increased the solubility of the complexes, and resulted in an increase in the rate of epimerization. Epimerization occured rapidly under mild conditions, and the same equilibrium point was reached regardless of whether the reaction was started from glucose or mannose. Among the ligands studied, N,N'-dialkylethyl-enediamine was the most active in C-2 epimerization.

  DOI：

  10.1016/0008-6215(91)80165-j
• 作为产物：
  描述：

  乙二醇己醚 在 Ni(Raney) 氢气 作用下， 生成 3-(2-hexyloxy-ethoxy)-propylamine
  参考文献：
  名称：

  Aldose epimerization by Ni(II): effect of ether-containing alkylenediamine ligands

  摘要：

  Several N-substituted ethylenediamine (en) Ni(II) derivatives containing ether linkages were prepared in order to study the effect of ligand structure on C-2 epimerization of aldohexoses. The reagent consisted of a Ni(II)-alkylenediamine derivative in methanol. The presence of ether linkages in the ligand increased the solubility of the complexes, and resulted in an increase in the rate of epimerization. Epimerization occured rapidly under mild conditions, and the same equilibrium point was reached regardless of whether the reaction was started from glucose or mannose. Among the ligands studied, N,N'-dialkylethyl-enediamine was the most active in C-2 epimerization.

  DOI：

  10.1016/0008-6215(91)80165-j

文献信息

• N-substituted bicyclo-(2.2.1)-5-heptene-2, 3-dicarboximides
  申请人：UNION CARBIDE CORP

  公开号：US02813877A1

  公开（公告）日：1957-11-19

  Imides of the formula <;FORM:0802741/IV (b)/1>; where R is C1-C10 alkyl, R1 is H or methy and n is 0-7, are prepared by reacting bicyclo-(2:2:1) - 5 - heptene - 2:3 - dicarboxylic anhydride with an amine <;FORM:0802741/IV (b)/2>; at 100-160 DEG C., preferably in the presence of an inert volatile organic solvent. The amines are prepared by adding acrylonitrile to the appropriate hydroxy compound to give <;FORM:0802741/IV (b)/3>; and catalytically hydrogenating the latter. Examples are given of the various stages of the process where (1) R is butyl and n is zero; (2) R is 2-ethylhexyl and n is zero; (3) R is hexyl, R1 is H and n is 1, 2 or 6; and (4) R is hexyl, R1 is methyl and n is 1. Many other products are mentioned. Specification 790,841 is referred to.ALSO:Insecticidal compositions contain an active ingredient and as extender or synergist therefor an imide of the formula <;FORM:0802741/VI/1>; where R is C1-C10 alkyl, R1 is H or methyl and n is 0-7. As much as 75 per cent of the active ingredient in a fly-spray composition can be replaced by the synergist, in the weight ratio of 1-80 parts for each part of active ingredient replaced. A typical composition contains 15-85 mg. of active ingredient per 100 c.c. of base, and 10-40 parts of synergist per part of active compound. The latter may be 3-(2-cyclopentenyl) - 2 - methyl - 4 - oxo - 2 - cyclopentenyl chrysanthemumate as in Specification 790,841. The compositions may be prepared as concentrates and diluted with water, oil or petroleum for use against insects and to protect agricultural crops, stored grain and packaged goods.

  公式为<;FORM:0802741/IV (b)/1>;的亚酰胺，其中R为C1-C10烷基，R1为H或甲基，n为0-7，通过将双环-(2:2:1) - 5 - 庚烯 - 2:3 - 二羧酸酐与胺<;FORM:0802741/IV (b)/2>;在100-160摄氏度下反应制备，最好在惰性挥发性有机溶剂的存在下。氨基化合物是通过向适当的羟基化合物中加入丙烯腈得到<;FORM:0802741/IV (b)/3>;，并对后者进行催化氢化制备的。给出了过程的各个阶段的示例，其中（1）R为丁基且n为零；（2）R为2-乙基己基且n为零；（3）R为己基，R1为H且n为1、2或6；（4）R为己基，R1为甲基且n为1。提及了许多其他产品。参考规范790,841。此外：杀虫剂组合物包含一种活性成分和作为延展剂或增效剂的公式为<;FORM:0802741/VI/1>;的亚酰胺，其中R为C1-C10烷基，R1为H或甲基，n为0-7。在飞行喷雾组合物中，多达75%的活性成分可以被增效剂替代，替代每份活性成分的重量比为1-80份。典型组合物每100毫升基料含有15-85毫克活性成分，每份活性化合物含有10-40份增效剂。后者可以是3-(2-环戊烯基) - 2 - 甲基 - 4 - 氧 - 2 - 环戊烯基菊酯，如规范790,841中所述。这些组合物可以制备为浓缩液，并与水、油或石油稀释，用于对抗昆虫并保护农作物、储存的谷物和包装货物。
• [EN] RIPK2 INHIBITORS<br/>[FR] INHIBITEURS DE RIPK2
  申请人：UNIV ALBERTA

  公开号：WO2019161495A1

  公开（公告）日：2019-08-29

  Compounds which inhibits RIPK2, and compositions including such compounds, as well as uses, methods and kits for treating a subject with, or suspected of having, inflammation, an inflammatory disorder and/or a cancer. The invention relates to compounds of Formulas (I), (II), (III), (IV) or (V), as defined herein and the pharmaceutically acceptable salts thereof.