18-methoxy-16(13->14)abeo-18a-homo-ent-halima-1(10),14,18a(18)Z-triene | 946052-01-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 18-methoxy-16(13->14)abeo-18a-homo-ent-halima-1(10),14,18a(18)Z-triene
• CAS: 946052-01-3
• 化学式: C₂₂H₃₆O
• 分子量: 316.527
• InChiKey: AMMUCOOSUFFHNZ-NGHPPWEISA-N

反应信息

• 作为反应物：
  描述：

  18-methoxy-16(13->14)abeo-18a-homo-ent-halima-1(10),14,18a(18)Z-triene 在 水 、 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以91%的产率得到16(13->14)abeo-18a-homo-ent-halima-1(10),14-dien-18-al
  参考文献：
  名称：

  Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid

  摘要：

  Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC50 in the low micromolar range. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.06.007
• 作为产物：
  描述：

  16(13->14)abeo-ent-halima-1(10),14-dien-18-al 、 甲氧基甲基三苯基氯化膦 在 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以91%的产率得到18-methoxy-16(13->14)abeo-18a-homo-ent-halima-1(10),14,18a(18)Z-triene
  参考文献：
  名称：

  Synthesis of novel antitumoural analogues of dysidiolide from ent-halimic acid

  摘要：

  Several sesterterpenolides analogues of dysidiolide have been synthesized and their in vitro antitumoural activity against human HeLa, A549, HT-29 and HL-60 carcinoma cells is presented. The proliferation inhibition data showed a significant antitumour activity of the compounds 1b, 2a, 2b, 3a, 3b, 4a, 4b, 5, inhibiting proliferation of distinct cancer cell types with an IC50 in the low micromolar range. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.06.007