2-({[5-Methyl-2-(propan-2-yl)cyclohexyl]oxy}carbonyl)benzoic acid | 53623-42-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-({[5-Methyl-2-(propan-2-yl)cyclohexyl]oxy}carbonyl)benzoic acid
• 英文别名: 2-[(5S)-5-methyl-2-propan-2-ylcyclohexyl]oxycarbonylbenzoic acid
• CAS: 53623-42-0
• 化学式: C₁₈H₂₄O₄
• 分子量: 304.4
• InChiKey: LJFJPDHXAWVDSA-FUJMWEONSA-N

物化性质

• 熔点：
  108-113 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• 海关编码：
  2918990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

文献信息

• Inhibitors of protein tyrosine phosphatases
  申请人：Indiana University Research and Technology Corporation

  公开号：US10072043B2

  公开（公告）日：2018-09-11

  Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

  本文公开了选择性抑制 PTP 酶家族成员的化合物。合成的化合物对 TC-PTP 具有选择性抑制作用。还提供了使用这些化合物的方法和含有这些化合物的制剂。还描述了一种荧光标记组合库合成和筛选方法。还介绍了使用这些化合物影响细胞和体外酶活性的方法，以及使用这些化合物治疗人类和动物疾病的方法。
• Generation of surface coating diversity
  申请人：Barden C Michael

  公开号：US20060083858A1

  公开（公告）日：2006-04-20

  The present invention relates to a surface discovery system comprising chemical compositions and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. This surface discovery platform is built upon a fundamental chemical unit refereed to as a synthon. Each synthon comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a passive (P) constituent and an active (A) constituent; a spacer unit (S) separating the backbone from a functional group; and a functional group (F). Variation of these synthon elements allows generation of large libraries surface coatings with a broad range of molecular and macroscopic properties. Further the spectrum of surfaces provided by the invention permits optimization of the wide range of solid-phase applications that involve surface immobilization of molecules.

  本发明涉及一种表面发现系统，包括化学成分和高通量组合合成方法，用于在固体基底上生成大量不同的表面涂层。该表面发现平台建立在一个基本化学单元（称为合成子）之上。每个合成子至少包括三个元素：固体基底上的化学骨架涂层，包括被动（P）成分和主动（A）成分；将骨架与官能团隔开的间隔单元（S）；以及官能团（F）。通过改变这些合成元素，可以生成具有多种分子和宏观特性的大型表面涂层库。此外，本发明所提供的表面谱允许对涉及分子表面固定的各种固相应用进行优化。
• VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER BETA-AMINOKETONE UND OPTISCH AKTIVER 1.3-AMINOALKOHOLE
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1504002B1

  公开（公告）日：2012-12-19
• GENERATION OF SURFACE COATING DIVERSITY
  申请人：Bio-Layer Pty Limited

  公开号：EP1534755B1

  公开（公告）日：2011-10-12
• Optically active B-aminoketones, optically active 1,3-amino alcohols and processes for preparing them
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US20040030145A1

  公开（公告）日：2004-02-12

  The invention relates to chiral Mannich bases of formula (I), chiral 1,3-amino alcohols of formula (II) derived therefrom, wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein, and to processes for preparing Mannich salts of formula (III) containing a chiral anion Y* − and compounds of ormulae (I) and (II), wherein R 1 , R 2 , R 3 , R 4 , R 5 and Y* − are as defined herein. 1