3-Oxo-2-methyl-2,3-dihydrobenzothiophen-1,1-dioxid | 16957-79-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Oxo-2-methyl-2,3-dihydrobenzothiophen-1,1-dioxid
• 英文别名: 2-Methyl-dihydro-thionaphthenon-(3)-1.1-dioxid；2-methylbenzo[b]thiophen-3(2H)-one 1,1-dioxide；2-methyl-1,1-dioxo-1-benzothiophen-3-one
• CAS: 16957-79-2
• 化学式: C₉H₈O₃S
• 分子量: 196.227
• InChiKey: MQLDRFDZRIIXAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  59.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Oxo-2-methyl-2,3-dihydrobenzothiophen-1,1-dioxid 在 lithium aluminium tetrahydride 、 2,4,6-三甲基苯磺酰肼 、 乙酸酐 、 potassium carbonate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙醚 、 二甲基亚砜 、 苯 为溶剂， 反应 23.0h， 生成 3-(1-benzylvinyl)-1,2-benzisothiazole
  参考文献：
  名称：

  Tamura, Yasumitsu; Bayomi, Said M. M.; Mukai, Chisato, Journal of the Chemical Society. Perkin transactions I, 1980, p. 2830 - 2834

  摘要：

  DOI：
• 作为产物：
  描述：

  3-hydroxy-2-methyl-1,1-dioxido-2,3-dihydrobenzo[b]thiophene 在 Jones reagent 作用下， 以 丙酮 为溶剂， 以86.6%的产率得到3-Oxo-2-methyl-2,3-dihydrobenzothiophen-1,1-dioxid
  参考文献：
  名称：

  一种芳环并[b]噻吩-3(2H)-酮-1,1-二氧化物 的制备方法

  摘要：

  本发明提供了一种芳环并[b]噻吩‑3(2H)‑酮‑1,1‑二氧化物的制备方法，所述方法为：将式I所示化合物与氧化剂反应得到所述芳环并[b]噻吩‑3(2H)‑酮‑1,1‑二氧化物；本发明还提供了式I所示化合物的制备方法；本发明提供的制备方法，反应收率高，反应速度快，原料易得，成本低、反应温和、易于控制、后处理简单、产生的废料极少、污染小，相比于现有方法中合成成本高、后处理繁琐，反应过程中三废多，污染大、收率低的缺陷，本发明提供的方法为绿色化工提供了一条切实可行合成路线，具有较高的生产应用价值。

  公开号：

  CN109293626B

文献信息

• METHODS TO INCREASE THE PHOTOSTABILITY OF DYES
  申请人：Hahn Klaus

  公开号：US20110046000A1

  公开（公告）日：2011-02-24

  The presently disclosed subject matter provides dyes having an improved photostability, biosensors comprising such dyes, and methods of use thereof, including methods for detecting target molecules in a sample under test and for live-cell imaging. The dyes can include a binding member, including a biomolecule or fragments thereof, which can interact with target molecules of interest and can be specific to a given conformational state or covalent modification, e.g., phosphorylation, of the target molecule. The presently disclosed dyes can be used for detecting changes in the binding, conformational change, or posttranslational modification of the target molecule.

  所述主题提供了具有改善光稳定性的染料、包括此类染料的生物传感器以及其使用方法，包括用于检测样品中的靶分子和用于活细胞成像的方法。该染料可以包括结合成员，包括生物分子或其片段，其可以与感兴趣的靶分子相互作用，并且可以特定于给定的构象状态或靶分子的共价修饰，例如磷酸化。目前披露的染料可用于检测靶分子的结合、构象变化或后翻译修饰的变化。
• TAMURA YASUMITSO; BAYOMI S. M. M.; MUKAI CHISATO; IKEDA MASAZUMI; KISE MA+, J. CHEM. SOC. PERKIN TRANS., PART 1, 1980, NO 12, 2830-2834
  作者：TAMURA YASUMITSO、 BAYOMI S. M. M.、 MUKAI CHISATO、 IKEDA MASAZUMI、 KISE MA+

  DOI：——

  日期：——
• NONLINEAR OPTICAL MATERIAL COMPOSITION AND METHOD OF MANUFACTURE
  申请人：Yamamoto Michiharu

  公开号：US20100152338A1

  公开（公告）日：2010-06-17

  Embodiments of the present disclosure provide non-linear optical compounds and compositions comprising a silole-derivative. In an embodiment, the silole derivative comprises a chromophore including a structure represented by Formula (A): wherein each Of R 1 , R 2 , R 3 , and R 4 are independently selected from the group consisting of a hydrogen atom, a C 1-10 linear alkyl group, a C 1-10 branched alkyl group, a C 5-10 aryl group, a heteroaryl group, an alkene group, an alkyne group, a cycloalkene, a cycloalkyne, and a substituted or unsubstituted heteroatom and X 1 and X 2 are each independently selected from the group consisting of O, S, and Se. Compositions formed from embodiments of the silole derivative may be used in non-linear optical devices, particularly passive and active optical waveguides.
• Targeted Covalent Probes and Inhibitors of Proteins Containing Redox-Sensitive Cysteines
  申请人：THE SCRIPPS RESEARCH INSTITUTE

  公开号：US20160195532A1

  公开（公告）日：2016-07-07

  Covalent, irreversible small-molecule inhibitors that modify the sulfenyl form (i.e., sulfenic acid, RSOH and sulfenamide, RSNR′2) of therapeutically important proteins (particularly kinases and phosphatases) are disclosed, where the compositions include a compound having a substituted aryl or heterocyclic core structure that promotes binding interactions with a specific protein, and a nucleophilic reaction center (carbon, nitrogen, sulfur, or phosphorous) that is capable of forming a covalent bond with a sulfenic acid- or sulfenamide-modified cysteine residue in the protein. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a chemical composition comprising an active compound toward a specific protein and for determining the potency of an inhibitor against a specific protein.
• US8835632B2
  申请人：——

  公开号：US8835632B2

  公开（公告）日：2014-09-16