2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile | 1268310-68-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile
• 英文别名: 2-[4-bromo-1-(cyclobutylmethyl)benzotriazol-5-yl]oxypyridine-3-carbonitrile
• CAS: 1268310-68-4
• 化学式: C₁₇H₁₄BrN₅O
• 分子量: 384.235
• InChiKey: QQMDMSUFRKXQAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  76.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氟-5-硝基苯胺 在 palladium 10% on activated carbon pyridinium hydrobromide perbromide 、 硫酸 、 水 、 氢气 、 potassium carbonate 、 溶剂黄146 、 N,N-二异丙基乙胺 、 sodium nitrite 作用下， 以 乙醇 、 氯仿 、 水 、 二甲基亚砜 、 乙腈 为溶剂， 反应 50.84h， 生成 2-{[4-bromo-1-(cyclobutylmethyl)-1H-benzotriazol-5-yl]oxy}pyridine-3-carbonitrile
  参考文献：
  名称：

  [EN] ETHER BENZOTRIAZOLE DERIVATIVES
  [FR] DÉRIVÉS D'ÉTHER DE BENZOTRIAZOLE

  摘要：

  本发明涉及醚苯并三唑衍生物，其是代谢型谷氨酸受体的增强剂，特别是mGluR2受体，并且在治疗或预防与谷氨酸功能障碍相关的神经系统和精神疾病以及代谢型谷氨酸受体参与的疾病中具有用途。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗代谢型谷氨酸受体参与的疾病中使用这些化合物和组合物。

  公开号：

  WO2011022312A1

文献信息

• ETHER BENZOTRIAZOLE DERIVATIVES
  申请人：Dudkin Vadim Y.

  公开号：US20120149677A1

  公开（公告）日：2012-06-14

  The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及一种乙醚苯并三唑衍生物，其为代谢型谷氨酸受体增强剂，特别是mGluR2受体，并且在治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病中具有用处。该发明还涉及包含这些化合物的制药组合物以及在预防或治疗代谢型谷氨酸受体参与的疾病中使用这些化合物和组合物。
• Ether benzotriazole derivatives
  申请人：Dudkin Vadim Y.

  公开号：US08975286B2

  公开（公告）日：2015-03-10

  The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及对乙醚苯并三唑衍生物，它们是代谢性谷氨酸受体的增效剂，特别是mGluR2受体，并且在治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及涉及代谢性谷氨酸受体的疾病中有用。本发明还涉及包含这些化合物的药物组成物以及在涉及代谢性谷氨酸受体的这种疾病的预防或治疗中使用这些化合物和组成物。
• US8975286B2
  申请人：——

  公开号：US8975286B2

  公开（公告）日：2015-03-10
• [EN] ETHER BENZOTRIAZOLE DERIVATIVES<br/>[FR] DÉRIVÉS D'ÉTHER DE BENZOTRIAZOLE
  申请人：MERCK SHARP & DOHME

  公开号：WO2011022312A1

  公开（公告）日：2011-02-24

  The present invention is directed to ether benzotriazole derivatives which are potentiators of metabotropic glutamate receptors, particularly the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及醚苯并三唑衍生物，其是代谢型谷氨酸受体的增强剂，特别是mGluR2受体，并且在治疗或预防与谷氨酸功能障碍相关的神经系统和精神疾病以及代谢型谷氨酸受体参与的疾病中具有用途。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗代谢型谷氨酸受体参与的疾病中使用这些化合物和组合物。