7β-acetoxy-6β-(piperidinoacetyloxy)-1α,9α-dihydroxy-8,13-epoxy-labd-14-en-11-one | 110452-76-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7β-acetoxy-6β-(piperidinoacetyloxy)-1α,9α-dihydroxy-8,13-epoxy-labd-14-en-11-one
• 英文别名: [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-acetyloxy-3-ethenyl-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-6-yl] 2-piperidin-1-ylacetate
• CAS: 110452-76-1
• 化学式: C₂₉H₄₅NO₈
• 分子量: 535.678
• InChiKey: SMKFOOQOQVAVIS-ZQVYKFDISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Process for the preparation of 6-acyl, 7-acyl and 6,7-diacyl analogues of forskolin and intermediates thereof
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0468444A1

  公开（公告）日：1992-01-29

  Process for the preparation of 6-acyl-, 7-acyl- or 6,7-diacyl analogues of forskolin of the general formula

  通式为 6-酰基、7-酰基或 6,7-二酰基的福斯克林类似物的制备工艺
• METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP
  申请人：Abraham Soman N.

  公开号：US20110171195A1

  公开（公告）日：2011-07-14

  Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.
• US5268471A
  申请人：——

  公开号：US5268471A

  公开（公告）日：1993-12-07