Cyanoethylthioquinoline | 887091-45-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Cyanoethylthioquinoline
• 英文别名: 3-quinolin-2-ylsulfanylpropanenitrile
• CAS: 887091-45-4
• 化学式: C₁₂H₁₀N₂S
• 分子量: 214.291
• InChiKey: DVWHUMGWQKQOMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  62
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-喹啉硫醇 、 丙烯腈 在 2C₂H₃O₂^(1-)*Pd⁽²⁺⁾*3Na⁽¹⁺⁾*C₁₈H₁₂O₉PS₃^(3-) 、 甘油 作用下， 反应 2.0h， 以91%的产率得到Cyanoethylthioquinoline
  参考文献：
  名称：

  甘油中的钯纳米颗粒：用于CX键形成和氢化过程的多功能催化系统

  摘要：

  AbstractPalladium nanoparticles stabilised by tris(3‐sulfophenyl)phosphine trisodium salt in neat glycerol have been synthesised and fully characterised, starting from both Pd(II) and Pd(0) species. The versatility of this innovative catalytic colloidal solution has been proved by its efficient application in CX bond formation processes (X=C, N, P, S) and CC multiple bond hydrogenation reactions. The catalytic glycerol phase could be recycled more than ten times, preserving its activity and selectivity. The scope of each of these processes has demonstrated the power of the as‐prepared catalyst, isolating the corresponding expected products in yields higher than 90%. The dual catalytic behaviour of this glycerol phase, associated to the metallic nanocatalysts used in wet medium (molecular‐ and surface‐like behaviour), has allowed attractive applications in one‐pot multi‐step transformations catalysed by palladium, such as CC coupling followed by hydrogenation, without isolation of intermediates using only one catalytic precursor.magnified image

  DOI：

  10.1002/adsc.201300753