7-[3-(R)-(1-aminocyclopropyl)pyrrolidin-1-yl]-8-cyano-1-[2-(S)-fluoro-1-(R)-cyclopropyl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | 431058-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-[3-(R)-(1-aminocyclopropyl)pyrrolidin-1-yl]-8-cyano-1-[2-(S)-fluoro-1-(R)-cyclopropyl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 7-[(3R)-3-(1-aminocyclopropyl)pyrrolidin-1-yl]-8-cyano-1-[(1R,2S)-2-fluorocyclopropyl]-4-oxoquinoline-3-carboxylic acid
• CAS: 431058-81-0
• 化学式: C₂₁H₂₁FN₄O₃
• 分子量: 396.421
• InChiKey: LUAJGHQKHYWIFI-XQAQDONZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (3R)-3-[1-(tert-butoxycarbonylamino)cyclopropan-1-yl]-1-[(S)-1-phenylethyl]pyrrolidine 在 钯 三乙烯二胺 、 氢气 作用下， 以 乙醇 、 二甲基亚砜 为溶剂， 生成 7-[3-(R)-(1-aminocyclopropyl)pyrrolidin-1-yl]-8-cyano-1-[2-(S)-fluoro-1-(R)-cyclopropyl]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  DEHALOGENO COMPOUNDS

  摘要：

  公开号：

  EP1336611B1

文献信息

• Dehalogeno compounds
  申请人：——

  公开号：US20040063754A1

  公开（公告）日：2004-04-01

  3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substitunets as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE. Thus these compounds are usable as drugs. 1

  具有特定取代基的3-(1-氨基环烷基)吡咯烷基取代的6-去卤代(氢取代)喹诺酮羧酸衍生物及其盐和水合物，如下式(I)所示，表现出广谱和强效的抗菌活性，对革兰氏阴性菌和革兰氏阳性菌均有效，特别是对革兰氏阳性球菌等耐药菌，包括MRSA、PRSP和VRE有良好的抗菌活性。因此这些化合物可用作药物。
• Dehalogeno-compounds
  申请人：Takahashi Hisashi

  公开号：US20070123560A1

  公开（公告）日：2007-05-31

  3-(1-Aminocycloalkyl)pyrrolidinyl-substituted-6-dehalodeno(hydrogen-substituted)quinolon carboxylic acid derivatives having specific substituents as represented by the following formula (I), its salts, and hydrates thereof exhibit a broad and potent antibacterial activity on gram-negative and gram-positive bacteria, in particular, resistant bacteria typified by gram-positive cocci, including MRSA, PRSP and VRE. Thus these compounds are usable as drugs.

  具有特定取代基的3-(1-氨基环烷基)吡咯烷基取代的6-去卤代（氢取代）喹诺酮羧酸衍生物，其盐和水合物，如以下公式（I）所示，表现出广谱和强效的抗菌活性，对革兰氏阴性和革兰氏阳性细菌均有效，特别是对革兰氏阳性球菌等耐药菌，包括MRSA、PRSP和VRE。因此，这些化合物可用作药物。
• 8-Cyanoquinolonecarboxylic Acid Derivative
  申请人：Takahashi Hisashi

  公开号：US20080255190A1

  公开（公告）日：2008-10-16

  To provide a quinolone antibacterial drug and a therapeutic agent for infectious diseases, which exhibit potent antibacterial activity on Gram-positive and Gram-negative bacteria and which is highly safe. A compound represented by the following formula (1): (wherein R 1 represents a C3-C6 cycloalkyl group which may have a substituent or the like; R 2 represents a hydrogen atom or the like; R 3 and R 4 each independently represent a hydrogen atom or a C1-C6 alkyl group, or a substituted carboxyl group derived from an amino acid, a dipeptide, or a tripeptide, and, in the case where each of R 3 and R 4 represents a C1-C6 alkyl group, the alkyl group may be substituted by one or more atoms or groups selected from among a hydroxyl group, a halogen atom, a C1-C6 alkylthio group, and a C1-C6 alkoxy group; and n denotes an integer of 1 to 3), a salt thereof, and a hydrate of the compound or the salt. Also, antibacterial drugs and therapeutic agents for infectious diseases are prepared.

  提供一种喹诺酮类抗菌药物和治疗传染病的药物，该药物对革兰氏阳性和革兰氏阴性细菌具有强效的抗菌活性，并且非常安全。化合物由以下公式（1）表示：（其中R1表示C3-C6环烷基，可以具有取代基或类似物；R2表示氢原子或类似物；R3和R4各自独立地表示氢原子或C1-C6烷基，或者由氨基酸，二肽或三肽衍生的取代羧基，如果R3和R4各自表示C1-C6烷基，则烷基可以被一个或多个从羟基，卤素原子，C1-C6烷硫基和C1-C6烷氧基中选择的原子或基取代；n表示1至3的整数），其盐和该化合物或盐的水合物。同时，还制备了抗菌药物和治疗传染病的药物。
• Fused substituted aminopyrrolidine derivative
  申请人：Takahashi Hisashi

  公开号：US20120108582A1

  公开（公告）日：2012-05-03

  A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

  提供了一种具有极好药物特性的喹诺酮合成抗菌剂，其不仅对革兰氏阴性菌具有强烈的抗菌活性，而且对对喹诺酮抗菌剂敏感度较低的革兰氏阳性球菌也具有强烈的抗菌活性，并表现出高安全性和优异的药代动力学特性。该化合物由式(I)或其盐或水合物表示，具体而言，是式(I)的喹诺酮衍生物，其中取代基R6和R7与它们所连接的碳原子一起形成一个环状结构，该环状结构可能包含一个氧原子作为环状成分原子，该环状结构形成一个5-4、5-5或5-6融合的双环吡咯烷基取代物，该取代物与含有吡啶苯并噁嗪结构的喹诺酮母骨架Q连接。
• Fused Substituted Aminopyrrolidine Derivative
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20140142096A1

  公开（公告）日：2014-05-22

  A quinolone synthetic antibacterial agent having excellent properties as a medicine is provided, which has strong antibacterial activity not only to Gram-negative bacteria but also to Gram-positive cocci that have low sensitivity to quinolone antibacterial agents, and which exhibits high safety and excellent pharmacokinetics. A compound represented by the formula (I) or a salt thereof, or a hydrate thereof. Specifically, a quinolone derivative of the formula (I) wherein substituents R6 and R7 taken together with the carbon atoms to which they are bonded form a cyclic structure which may contain an oxygen atom as a ring constituent atom, the cyclic structure forming a 5-4, 5-5, or 5-6 fused bicyclic pyrrolidinyl substituent, the substituent being bonded to a quinolone mother skeleton Q containing a pyridobenzoxazine structure.

  提供了一种具有出色药物特性的喹诺酮合成抗菌剂，它不仅对革兰氏阴性菌具有强烈的抗菌活性，而且对对喹诺酮抗菌剂敏感性较低的革兰氏阳性球菌也具有强烈的抗菌活性，并且具有高安全性和优异的药代动力学。化合物由式(I)或其盐或其水合物表示，具体来说，是式(I)的喹诺酮衍生物，其中取代基R6和R7与它们连接的碳原子一起形成一个环状结构，该环状结构可以包含一个氧原子作为环构成原子，该环状结构形成一个5-4、5-5或5-6融合的双环吡咯烷基取代基，该取代基与含有吡啶并苯并噁嗪结构的喹诺酮母骨架Q连接。