2-{2-[2-(4-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxymethyl}-benzyloxy)-ethoxy]-ethoxy}-ethanol | 146063-45-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-{2-[2-(4-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxymethyl}-benzyloxy)-ethoxy]-ethoxy}-ethanol
• 英文别名: 2-[2-[2-[[4-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxymethyl]phenyl]methoxy]ethoxy]ethoxy]ethanol
• CAS: 146063-45-8
• 化学式: C₂₀H₃₄O₈
• 分子量: 402.485
• InChiKey: RAHGBOUIODMNAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.77
• 重原子数：
  28.0
• 可旋转键数：
  20.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  95.84
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  2-{2-[2-(4-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxymethyl}-benzyloxy)-ethoxy]-ethoxy}-ethanol 在 咪唑 、 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 Toluene-4-sulfonic acid 2-(2-{2-[4-(2-{2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzyloxy]-ethoxy}-ethoxy)-ethyl ester
  参考文献：
  名称：

  Toward Controllable Molecular Shuttles

  摘要：

  AbstractA number of nanometer‐scale molecular assemblies, based on rotaxane‐type structures, have been synthesized by means of a template‐directed strategy from simple building blocks that, on account of the molecular recognition arising from the noncovalent interactions between them, are able to self‐assemble into potential molecular abacuses. In all the cases investigated, the π‐electron‐deficient tetracationic cyclophane cyclobis(paraquat‐p‐phenylene) is constrained mechanically around a dumbbell‐shaped component consisting of a linear polyether chain intercepted by at least two, if not three, π‐electron‐rich units and terminated at each end by blocking groups or stoppers. The development of an approach toward constructing these molecular abacuses, in which the tetracationic cyclophane is able to shuttle back and forth with respect to the dumbbell‐shaped component, begins with the self‐assembly of a [2]rotaxane consisting of two hydroquinone rings symmetrically positioned within a polyether chain terminated by triisopropylsilyl ether blocking groups. In this first so‐called molecular shuttle, the tetracationic cyclophane oscillates in a degenerate fashion between the two π‐electron‐rich hydroquinone rings. Replacement of one of the hydroquinone rings—or the insertion of another π‐electron‐rich ring system between the two hydroquinine rings—introduces the possibility of translational isomerism, a phenomenon that arises because of the different relative positions and populations of the tetracationic cyclophane with respect to the π‐donor sites on the dumbbell‐shaped component. In two subsequent [2]rotaxanes, one of the hydroquinone rings in the dumbbell‐shaped component is replaced, first by a p‐xylyl and then by an indole unit. Finally, a tetrathiafulvalene (TTF) unit is positioned between two hydroquinone rings in the dumbbell‐shaped component. Spectroscopic and electrochemical investigations carried out on these first‐generation molecular shuttles show that they could be developed as molecular switches.

  DOI：

  10.1002/chem.19970030719
• 作为产物：
  描述：

  1,4-二(溴甲基)苯 、 三乙二醇 在 silver(l) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 3.5h， 以55%的产率得到2-{2-[2-(4-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxymethyl}-benzyloxy)-ethoxy]-ethoxy}-ethanol
  参考文献：
  名称：

  硫醚金（III）配合物的光还原：机理见解和均相催化。

  摘要：

  AuCl 3和硫醚配体之间形成的络合物在二氯甲烷和甲苯溶液中的均相条件下进行光诱导的还原消除，得到相应的Au I络合物。在365 nm辐射或环境光下，所有的金（III）配合物都迅速还原为氯化金（I）配合物，同时在55°C以下具有热稳定性。通过动力学研究和对氯物种：Cl 2，自由基Cl的化学捕集，讨论了通过消除Cl 2进行光还原的机理。，可能还有Cl +。在将N-炔丙基酰胺合成恶唑的过程中，评估了氯化金（III）配合物和通过原位还原获得的相应金（I）配合物的催化活性。这种光可还原络合物在均相金催化中的优点通过硫醚金络合物催化的级联反应得以说明，该级联反应可高产率提供4 H-喹啉嗪-4-酮。

  DOI：

  10.1002/chem.201804322