1-hydroxy-1-methyl-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-2(4H)-one | 33117-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-hydroxy-1-methyl-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-2(4H)-one
• 英文别名: 1-hydroxy-1-methyl-5,6-dihydro-1H,4H-pyrrolo[3,2,1-ij]quinolin-2-one；3-Hydroxy-3-methyl-1-azatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-2-one；3-hydroxy-3-methyl-1-azatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-trien-2-one
• CAS: 33117-69-0
• 化学式: C₁₂H₁₃NO₂
• 分子量: 203.241
• InChiKey: CFPJFMLTYMAWMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(3.4-dihydroquinolin-1-(2H)-yl)propane-1,2-dinone 在 三氟乙酸 、 水 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 以85%的产率得到1-hydroxy-1-methyl-5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-2(4H)-one
  参考文献：
  名称：

  Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-N-Anilides

  摘要：

  Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 degrees C. alpha-Iminocarboxamides, generated in situ from ketoamides, cyclized similarly to 3-aminooxindoles under identical conditions,

  DOI：

  10.1021/ol202263a

文献信息

• Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-<i>N</i>-Anilides
  作者：Ioulia Gorokhovik、Luc Neuville、Jieping Zhu

  DOI：10.1021/ol202263a

  日期：2011.10.21

  Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 degrees C. alpha-Iminocarboxamides, generated in situ from ketoamides, cyclized similarly to 3-aminooxindoles under identical conditions,