yadanzioside D | 95258-19-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: yadanzioside D
• 英文别名: methyl (1R,2S,3R,6R,8S,11S,12S,13S,14R,15R,16S,17S)-3-acetyloxy-12,15,16-trihydroxy-9,13-dimethyl-4-oxo-11-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate
• CAS: 95258-19-8
• 化学式: C₂₉H₄₀O₁₆
• 分子量: 644.627
• InChiKey: IPVONKABOQLBGH-POUVBQLVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  45
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  248
• 氢给体数：
  7
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  yadanzioside D 在 β-glucosidase 作用下， 生成 yadanzioside D aglycone
  参考文献：
  名称：

  New quassinoid glycosides, yadanziosides A-H, from Brucea javanica.

  摘要：

  从鸦胆子种子中分离出了八种新的抗白血病类槲皮苷，即yadanziosides A-H（1-8），并通过化学转化和光谱分析确定了它们的结构。

  DOI：

  10.1248/cpb.32.4702

文献信息

• New quassinoid glycosides, yadanziosides A-H, from Brucea javanica.
  作者：Toshiro Sakaki、Shin Yoshimura、Masami Ishibashi、Takahiko Tsuyuki、Takeyoshi Takahashi、Tadashi Honda、Toshihiro Nakanishi

  DOI：10.1248/cpb.32.4702

  日期：——

  Eight new antileukemic quassinoid glycosides, yadanziosides A-H (1-8) were isolated from seeds of Brucea javanica and their structures were determined by chemical transformation and spectral analysis.

  从鸦胆子种子中分离出了八种新的抗白血病类槲皮苷，即yadanziosides A-H（1-8），并通过化学转化和光谱分析确定了它们的结构。
• Structures of New Quassinoid Glycosides, Yadanziosides A, B, C, D, E, G, H, and New Quassinoids, Dehydrobrusatol and Dehydrobruceantinol from<i>Brucea javanica</i>(L.) MERR
  作者：Toshiro Sakaki、Shin Yoshimura、Masami Ishibashi、Takahiko Tsuyuki、Takeyoshi Takahashi、Tadashi Honda、Toshihiro Nakanishi

  DOI：10.1246/bcsj.58.2680

  日期：1985.9

  Quassinoid glycosides, yadanziosides A, B, C, D, E, G, and H, and two quassinoids, dehydrobrusatol and dehydrobruceantinol were isolated from seeds of Brucea javanica, and their structures were determined. These glycosides showed bitter taste and were demonstrated to have antileukemic activity.

  从Brucea javanica种子中分离出了槲皮苷--yadanziosides A、B、C、D、E、G和H，以及两种槲皮苷--dehydrobrusatol和dehydrobruceantinol，并确定了它们的结构。这些苷具有苦味，并被证明具有抗白血病活性。