quinoline-2,4-diyl bis(trifluoromethanesulfonate) | 1161940-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: quinoline-2,4-diyl bis(trifluoromethanesulfonate)
• 英文别名: 2,4-Bis(trifluoromethylsulfonyloxy)quinoline；[2-(trifluoromethylsulfonyloxy)quinolin-4-yl] trifluoromethanesulfonate
• CAS: 1161940-99-3
• 化学式: C₁₁H₅F₆NO₆S₂
• 分子量: 425.286
• InChiKey: YHDPISQXKZNKDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  116
• 氢给体数：
  0
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  quinoline-2,4-diyl bis(trifluoromethanesulfonate) 在 乙酰氯 、 sodium iodide 作用下， 以 乙腈 为溶剂， 以97%的产率得到2,4-diiodoquinoline
  参考文献：
  名称：

  Microwave-Assisted Trans-Halogenation Reactions of Various Chloro-, Bromo-, Trifluoromethanesulfonyloxy- and Nonafluorobutanesulfonyloxy-Substituted Quinolines, Isoquinolines, and Pyridines Leading to the Corresponding Iodinated Heterocycles

  摘要：

  Microwave irradiation of certain chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines in the presence of acetic. anhydride and sodium iodide leads, via a trans-halogenation process, to the corresponding iodides in high yield. Related conversions involving pyridines and isoquinolines can also be achieved under similar conditions.

  DOI：

  10.1021/jo9008386
• 作为产物：
  描述：

  三氟甲磺酸酐 、 2,4-喹啉二醇 在 吡啶 作用下， 反应 24.0h， 以16%的产率得到quinoline-2,4-diyl bis(trifluoromethanesulfonate)
  参考文献：
  名称：

  Microwave-Assisted Trans-Halogenation Reactions of Various Chloro-, Bromo-, Trifluoromethanesulfonyloxy- and Nonafluorobutanesulfonyloxy-Substituted Quinolines, Isoquinolines, and Pyridines Leading to the Corresponding Iodinated Heterocycles

  摘要：

  Microwave irradiation of certain chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines in the presence of acetic. anhydride and sodium iodide leads, via a trans-halogenation process, to the corresponding iodides in high yield. Related conversions involving pyridines and isoquinolines can also be achieved under similar conditions.

  DOI：

  10.1021/jo9008386

文献信息

• Microwave-Assisted Trans-Halogenation Reactions of Various Chloro-, Bromo-, Trifluoromethanesulfonyloxy- and Nonafluorobutanesulfonyloxy-Substituted Quinolines, Isoquinolines, and Pyridines Leading to the Corresponding Iodinated Heterocycles
  作者：Alex C. Bissember、Martin G. Banwell

  DOI：10.1021/jo9008386

  日期：2009.7.3

  Microwave irradiation of certain chloro-, bromo-, trifluoromethanesulfonyloxy- and nonafluorobutanesulfonyloxy-substituted quinolines in the presence of acetic. anhydride and sodium iodide leads, via a trans-halogenation process, to the corresponding iodides in high yield. Related conversions involving pyridines and isoquinolines can also be achieved under similar conditions.