2-amino-3-(4-bromophenyl)-6,7-dimethoxyquinoline 1-oxide | 1393939-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-amino-3-(4-bromophenyl)-6,7-dimethoxyquinoline 1-oxide
• CAS: 1393939-19-9
• 化学式: C₁₇H₁₅BrN₂O₃
• 分子量: 375.222
• InChiKey: IHSBSFGFVFDWJY-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-(4-Bromophenyl)-3-(4,5-dimethoxy-2-nitrophenyl)prop-2-enenitrile 在 tin(II) chloride dihdyrate 、 盐酸 、 水 作用下， 以 乙醇 为溶剂， 以70%的产率得到2-amino-3-(4-bromophenyl)-6,7-dimethoxyquinoline 1-oxide
  参考文献：
  名称：

  Novel and efficient synthesis of substituted quinoline-1-oxides and the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) with the aid of stannous chloride

  摘要：

  A novel and efficient approach to the synthesis of substituted quinoline-1-oxides and the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) was developed. The reaction has fancy selectivity when 3-(2-nitrophenyl)acrylonitriles were treated with the aid of SnCl2 reagent under the same conditions. When R is -CN or -COOR' the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) were obtained. Whereas, when R is H or aryl another series of substituted quinoline-1-oxides were formed. The products have been screened for their anticancer activities. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.07.049