(2S,4HR,6aR,7R,9S,10aS,10bR)-9-(4-nitrobenzoylamino)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyI-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester | 917506-34-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (2S,4HR,6aR,7R,9S,10aS,10bR)-9-(4-nitrobenzoylamino)-2-(3-furanyl)-dodecahydro-6a,10b-dimethyI-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
• 英文别名: methyl (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(furan-3-yl)-6a,10b-dimethyl-9-[(4-nitrobenzoyl)amino]-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f]isochromene-7-carboxylate
• CAS: 917506-34-4
• 化学式: C₂₈H₃₀N₂O₉
• 分子量: 538.554
• InChiKey: QCQPCFJRINORLB-XAGHGKQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  158
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• OPIOID RECEPTOR LIGANDS
  申请人：Bohn Laura M.

  公开号：US20090088466A1

  公开（公告）日：2009-04-02

  The invention provides novel compounds of formula (I), (II), (III), and (IV). The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to an animal in need of treatment. The invention also provides therapeutic methods for the use of compounds of formula (V), as well as methods for treating diseases by administering such compounds.

  本发明提供了化合物(I)、(II)、(III)和(IV)的新型化合物。本发明还提供了包含这些化合物的药物组合物，以及通过向需要治疗的动物施用这些化合物来治疗与阿片受体功能相关的疾病的方法。本发明还提供了化合物(V)的治疗方法，以及通过施用这些化合物来治疗疾病的方法。
• [EN] OPIOID RECEPTOR LIGANDS<br/>[FR] LIGANDS DE RECEPTEUR OPIOIDE
  申请人：UNIV IOWA RES FOUND

  公开号：WO2006138589A2

  公开（公告）日：2006-12-28

  [EN] The invention provides novel compounds of formula (I), (II), (III), and (IV). The invention also provides pharmaceutical compositions comprising such compounds as well as methods for treating diseases associated with opioid receptor function by administering such compounds to an animal in need of treatment. The invention also provides therapeutic methods for the use of compounds of formula (V), as well as methods for treating diseases by administering such compounds.
  [FR] Composés de formule (I), (II), (III), et (IV). Compositions pharmaceutiques les renfermant et procédés de traitement de maladies associées à la fonction du récepteur opioïde par administration de ces composés à un animal à traiter. Enfin, procédés thérapeutiques reposant sur l'utilisation des composés de formule (V), et procédés de traitement de maladies par administration des composés considérés.