4-(2-溴乙酰基)-2,6-二甲氧基苯基乙酸酯 | 28294-48-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-(2-溴乙酰基)-2,6-二甲氧基苯基乙酸酯
• 英文名称: 4-Acetoxy-3,5-dimethoxy-α-brom-acetophenon
• 英文别名: 4-Acetoxy-ω-brom-3,5-dimethyoxyacetophenon；4-(bromoacetyl)-2,6-dimethoxyphenyl acetate；4-(2-Bromoacetyl)-2,6-dimethoxyphenyl acetate；[4-(2-bromoacetyl)-2,6-dimethoxyphenyl] acetate
• CAS: 28294-48-6
• 化学式: C₁₂H₁₃BrO₅
• 分子量: 317.136
• InChiKey: DQLCIZRXDSMYEF-UHFFFAOYSA-N

物化性质

• 熔点：
  126-127 °C
• 密度：
  1.442

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2915390090

反应信息

• 作为反应物：
  描述：

  4-(2-溴乙酰基)-2,6-二甲氧基苯基乙酸酯 在 potassium carbonate 、 potassium iodide 作用下， 以 二甲基亚砜 、 丙酮 为溶剂， 生成 4-(2-(4-formyl-2,6-dimethoxyphenoxy)-3-hydroxypropanoyl)-2,6-dimethoxyphenyl acetate
  参考文献：
  名称：

  Miksche,G., Acta Chemica Scandinavica (1947), 1973, vol. 27, p. 1355 - 1368

  摘要：

  DOI：
• 作为产物：
  描述：

  4'-O-乙酰基乙酰丁香酮 在 溴 作用下， 以 氯仿 为溶剂， 生成 4-(2-溴乙酰基)-2,6-二甲氧基苯基乙酸酯
  参考文献：
  名称：

  Miksche,G., Acta Chemica Scandinavica (1947), 1973, vol. 27, p. 1355 - 1368

  摘要：

  DOI：

文献信息

• Derivatives of heterocycles with 5 members, their preparation and their use as medicaments
  申请人：——

  公开号：US20040132788A1

  公开（公告）日：2004-07-08

  The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) 1 wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R 1 and R 2 are notably independently hydrogen, alkyl or cycloalkyl and &OHgr; is —NR 46 R 47 or —OR 48 R 46 and R 47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH 2 ) k —COOR 51 , R 51 is notably alkyl or haloalkyl and R 48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.

  本发明涉及噻唑、噁唑、咪唑、异噁唑和异噁唑啉的一般式(I)衍生物，其中Het为噻唑、噁唑、咪唑、异噁唑或异噁唑啉，n为0至6的整数，A特别选自各种可任选取代的芳香族基团，B特别为氢、烷基或苯基，R1和R2特别独立地为氢、烷基或环烷基，Ω为—NR46R47或—OR48，R46和R47特别独立地为氢、烷基、环烷基或—(CH2)k—COOR51，R51特别为烷基或卤代烷基，R48特别为氢或烷基。这些化合物具有有利的药理学特性，使其可用于治疗学，特别是用于治疗神经退行性疾病或疼痛。
• 4-PHENYLTHIAZOLE AND 4-PHENYLIMIDIZOLE DERIVATIVES AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES, PAIN AND EPILEPSY
  申请人：CHABRIER de LASSAUNIERE Pierre-Etienne

  公开号：US20080108683A1

  公开（公告）日：2008-05-08

  The invention relates to novel derivatives of 4-phenylthiazoles and 4-phenylimidizoles and the use thereof as medicaments. The invention especially relates to the following compounds: butyl-2-[4-(4-aminophenyl)-1H-imidizol-2-yl]ethyl-carbamate, and 4-[2-(1-aminocyclopentyl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol, and the salts of the same.

  本发明涉及4-苯基噻唑和4-苯基咪唑的新衍生物及其作为药物的用途。本发明特别涉及以下化合物：丁基-2-[4-(4-氨基苯基)-1H-咪唑-2-基]乙基-氨基甲酸酯，以及4-[2-(1-氨基环戊基)-1,3-噻唑-4-基]-2,6-二叔丁基苯酚及其盐。
• 4-Phenlthiazole and 4-phenylimidizole derivatives and their use as medicaments for the treatment of neurodegenerative diseases, pain and epilepsy
  申请人：Chabrier de Lassauniere Pierre-Etienne

  公开号：US20070054900A1

  公开（公告）日：2007-03-08

  The invention relates to novel derivatives of 4-phenylthiazoles and 4-phenylimidazoles and the use thereof medicament. The invention especially relates to the following compounds: butyl-2-[4-(4-(aminophenyl)-1H-imidazol-2-yl]ethyl-carbamate, and 4-[2-(1-aminocyclopentyl)-1,3-thiazol-4-yl]-2,6-di-tert-butylphenol, and the salts of the same.

  该发明涉及4-苯基噻唑和4-苯基咪唑的新衍生物及其药物用途。该发明特别涉及以下化合物：丁基-2-[4-(4-(氨基苯基)-1H-咪唑-2-基)]乙基氨基甲酸酯，以及4-[2-(1-氨基环戊基)-1,3-噻唑-4-基]-2,6-二叔丁基苯酚，以及其盐。
• DERIVATIVES OF HETEROCYCLES WITH 5 MEMBERS, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
  申请人：CHABRIER DE LASSAUNIERE Pierre-Etienne

  公开号：US20110172434A1

  公开（公告）日：2011-07-14

  The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R 1 and R 2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR 46 R 47 or —OR 48 , R 46 and R 47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH 2 ) k —COOR 51 , R 51 is notably alkyl or haloalkyl and R 48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.

  本发明涉及通式（I）的噻唑，噁唑，咪唑，异噁唑和异噁唑啉衍生物，其中Het为噻唑，噁唑，咪唑，异噁唑或异噁唑啉，n为0至6的整数，A特别选择自各种可选取代的芳香基团，B特别为氢，烷基或苯基，R1和R2特别独立地为氢，烷基或环烷基，Ω为—NR46R47或—OR48，R46和R47特别独立地为氢，烷基，环烷基或—(CH2)k—COOR51，R51特别为烷基或卤代烷基，R48特别为氢或烷基。这些化合物具有有利的药理学性质，可以在治疗中使用，特别用于治疗神经退行性疾病或疼痛。
• 10.1039/d4gc02156h
  作者：Danlu, Zhang、Xu, Zeng、Sinong, Wang、Yan, Xu、Qiqi, Dai、Fengxia, Yue、Peng, Wang、Chuanfu, Liu、Wu, Lan

  DOI：10.1039/d4gc02156h

  日期：——

  Electrochemical catalysis emerges as a promising method for lignin depolymerization due to its environmental friendliness and mild reaction condition. Metal oxyhydroxides have displayed appealing electrochemical activity for the oxidation for various biomass substrates. In this study, we prepared different metal (Ni, Co, Mn, Fe, and Cu) oxyhydroxides on nickel foam electrodes through electrodeposition

  电化学催化由于其环境友好和反应条件温和而成为木质素解聚的一种有前途的方法。金属羟基氧化物对于各种生物质底物的氧化表现出有吸引力的电化学活性。在这项研究中，我们通过电沉积在泡沫镍电极上制备了不同的金属（Ni、Co、Mn、Fe 和 Cu）羟基氧化物。表征了它们的电化学性质，并使用木质素模型化合物研究了木质素氧化裂解的反应性。与其他金属羟基氧化物相比，NiOOH 对 β-O-4 键的氧化裂解表现出显着更高的活性，导致芳香族单体的产率为 93%，对苯甲酸的选择性为 99%。此外，通过原位测试揭示了活性位点NiOOH的重构过程，并探讨了反应机理。非酚结构为C β –C γ /C β –O 或C α –C β