1-(t-butyldimethylsilyloxy)-6-methyl-5-(2-quinolinylmethoxy)heptane | 142820-27-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(t-butyldimethylsilyloxy)-6-methyl-5-(2-quinolinylmethoxy)heptane
• CAS: 142820-27-7
• 化学式: C₂₄H₃₉NO₂Si
• 分子量: 401.665
• InChiKey: RFDKJQKWRMHLPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.97
• 重原子数：
  28.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  31.35
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-(t-butyldimethylsilyloxy)-6-methyl-5-(2-quinolinylmethoxy)heptane 以 乙腈 为溶剂， 反应 2.5h， 以62%的产率得到7-(t-butyldimethylsilyloxy)-2-methyl-3-heptanone
  参考文献：
  名称：

  Quinaldyl ethers as latent carbonyl functions

  摘要：

  Ketones can be generated from secondary alcohols by converting the latter into quinaldine ethers followed by irradiaten (>320 nm). The quinaldine ethers can therefore be utilized as latent carbonyl groups. The quinaldine group is chemically inert during transformations at other parts of the molecule involving hydroboration, Grignard reagents, LiAlH4, as well as bromine or ozone.

  DOI：

  10.1016/s0040-4020(01)81226-6
• 作为产物：
  描述：

  2-(氯甲基)喹啉 在 sodium hydroxide 、 9-borabicyclo[3.3.1]nonane dimer 、 双氧水 、 sodium hydride 、 lithium bromide 作用下， 以 四氢呋喃 为溶剂， 反应 9.0h， 生成 1-(t-butyldimethylsilyloxy)-6-methyl-5-(2-quinolinylmethoxy)heptane
  参考文献：
  名称：

  Quinaldyl ethers as latent carbonyl functions

  摘要：

  Ketones can be generated from secondary alcohols by converting the latter into quinaldine ethers followed by irradiaten (>320 nm). The quinaldine ethers can therefore be utilized as latent carbonyl groups. The quinaldine group is chemically inert during transformations at other parts of the molecule involving hydroboration, Grignard reagents, LiAlH4, as well as bromine or ozone.

  DOI：

  10.1016/s0040-4020(01)81226-6