2-methylene-5-[bis(4-methylphenyl)-methylene]cyclopentanone | 1048972-57-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-methylene-5-[bis(4-methylphenyl)-methylene]cyclopentanone
• 英文别名: 2-[Bis(4-methylphenyl)methylidene]-5-methylidenecyclopentan-1-one
• CAS: 1048972-57-1
• 化学式: C₂₁H₂₀O
• 分子量: 288.389
• InChiKey: SEUYVXAULGGTJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• 2-METHYLENE-5-SUBSTITUTED-METHYLENECYCLOPENTANONE DERIVATIVES AND USE THEREOF
  申请人：Zhao Linxiang

  公开号：US20110060054A1

  公开（公告）日：2011-03-10

  The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.

  本发明涉及2-亚甲基-5-取代-亚甲基环戊酮衍生物，其具有公式I的结构，以及这些衍生物的用途。公式I的衍生物作为活性成分，可用于制备治疗和/或预防诸如乳腺癌、肺癌、结肠癌、直肠癌、胃癌、前列腺癌、膀胱癌、子宫癌、胰腺癌和卵巢癌等癌症疾病的药物。本发明的活性化合物可以单独用作抗癌药物，或与一个或多个其他抗肿瘤药物联合使用。可以通过同时、随后或分别给药每个治疗成分来进行联合治疗。
• 2-METHYLENE-5-SUBSTITUTED METHYLENE CYCLOPENTANONE DERIVATIVES AND USE THEREOF
  申请人：Shenyand Pharmaceutical University

  公开号：EP2248796A1

  公开（公告）日：2010-11-10

  The invention relates to 2-methylene-5-substituted-methylenecyclopentanone derivatives of formula I, and the use thereof. The derivatives of formula I as active components are useful for preparing a medicine for the treatment and/or prevention of cancer diseases such as breast cancer, lung cancer, colon cancer, rectal cancer, stomach cancer, prostate cancer, bladder cancer, uterus cancer, pancreatic cancer and ovary cancer. The active compounds of the invention may be used as an anticancer drug alone or used in combination with one or more other antitumor drugs. A combined therapy can be carried out by administrating each therapeutic component concurrently, subsequently or separately.

  本发明涉及式 I 的 2-亚甲基-5-取代亚甲基环戊酮衍生物及其用途。式 I 的衍生物作为活性成分可用于制备治疗和/或预防癌症疾病的药物，如乳腺癌、肺癌、结肠癌、直肠癌、胃癌、前列腺癌、膀胱癌、子宫癌、胰腺癌和卵巢癌。本发明的活性化合物可单独用作抗癌药物，也可与一种或多种其他抗肿瘤药物联合使用。可以通过同时、随后或分别施用每种治疗成分来进行联合治疗。
• US8415505B2
  申请人：——

  公开号：US8415505B2

  公开（公告）日：2013-04-09