| 213546-35-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子
• CAS: 213546-35-1
• 化学式: C₆₆H₆₇NO₁₀
• 分子量: 1034.26
• InChiKey: TYAKRVZWYHMMOW-UFYVVDQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.49
• 重原子数：
  77.0
• 可旋转键数：
  14.0
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  157.69
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  在 溶剂黄146 、 三氟乙酸 、 亚硝酸异戊酯 作用下， 以 异戊醇 、 氯仿 为溶剂， 生成 phorbol 12-(4-pyrenebutyrate) 13-diazoacetate
  参考文献：
  名称：

  Photoaffinity labeling of PKC with a phorbol derivative: Importance of the 13-acyl group in phorbol ester-PKC interaction

  摘要：

  We report the design and synthesis of a novel photoaffinity ligand, phorbol 12-(1-pyrenebutyrate) 13-diazoacetate (PPDA, 6). This photolabile phorbol derivative labeled with tritium was used for photocrosslinking experiments with a sample of PKC partially purified from rat brain, and specific binding of 6 to PKC was observed.

  DOI：

  10.1016/0040-4039(95)01864-e
• 作为产物：
  描述：

  phorbol 20-trityl 在 4-二甲氨基吡啶 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Photoaffinity labeling of PKC with a phorbol derivative: Importance of the 13-acyl group in phorbol ester-PKC interaction

  摘要：

  We report the design and synthesis of a novel photoaffinity ligand, phorbol 12-(1-pyrenebutyrate) 13-diazoacetate (PPDA, 6). This photolabile phorbol derivative labeled with tritium was used for photocrosslinking experiments with a sample of PKC partially purified from rat brain, and specific binding of 6 to PKC was observed.

  DOI：

  10.1016/0040-4039(95)01864-e

文献信息

• Photoaffinity labeling of PKC isozymes by phorbol ester derivatives
  作者：Koichiro Uotsu、Mikiko Sodeoka、Masakatsu Shibasaki

  DOI：10.1016/s0968-0896(98)00068-6

  日期：1998.7

  Photoaffinity probes PPDA and PPTD, which have diazoacetyl and trifluorodiazopropionyl group at C-13 position in phorbol, respectively, were synthesized. Photoaffinity labeling of protein kinase C isozymes by both the probes resulted in specific cross-linking. (C) 1998 Elsevier Science Ltd. All rights reserved.