N-nor-evoxanthine | 5473-09-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-nor-evoxanthine
• 英文别名: exo,exo-3,5-dibromonortricyclane；3exo,5exo-dibromo-2,6-cyclo-norbornane；3exo,5exo-Dibrom-2,6-cyclo-norbornan
• CAS: 5473-09-6；75685-55-1；75685-56-2
• 化学式: C₇H₈Br₂
• 分子量: 251.949
• InChiKey: SYFIGJNFOVWPEX-XNFWEBLWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  9.0
• 可旋转键数：
  0.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  2,5-降冰片二烯 在 氯仿 、 溴 作用下， 生成 N-nor-evoxanthine 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  双环[2.2.2]十八碳二烯（2.5）二溴化物的结构和溶剂分解。双环[2.2.2]辛烷系列。第三次沟通

  摘要：

  双环[2.2.2]辛二烯-（2,5）（1）的溴化反应生成反式-2,3-二溴-双环[2.2.2]辛烯-（5）（9）和反式-3的混合物，比例为7：3的5-二溴-高三环烯（7a）。该结果是通过解释的内加入溴（1）与形成中间高烯丙基离子（23）或可能的话，不寻常的对称桥接溴离子（24）。

  DOI：

  10.1002/hlca.19590420602

文献信息

• BICYCLOHEPTADIENE DIBROMIDES
  作者：S. Winstein

  DOI：10.1021/ja01467a058

  日期：1961.3
• Effects of Lycopene and Sho-saiko-to on Hepatocarcinogenesis in a Rat Model of Spontaneous Liver Cancer
  作者：Seishiro Watanabe、Yukihiro Kitade、Tsutomu Masaki、Mikio Nishioka、Kimihiko Satoh、Hoyoku Nishino

  DOI：10.1207/s15327914nc391_13

  日期：2001.1

  The Long-Evans Cinnamon (LEC) rat is a well-characterized model of spontaneous hepatocarcinogenesis. It has been shown that dietary administration of lycopene or the herbal medicine Sho-saiko-to (TJ-9) has anticarcinogenic activity, although the mechanism by which these products protect against carcinogenesis is not well known. We investigated the outcome of administration of lycopene and TJ-9 on the occurrence of hepatic neoplasia in LEC rats. A diet containing 0.005% lycopene (originally the product of tomato oleoresin containing 13% lycopene) and 1% TJ-9 (crude extracts of 7 herbs: bupleurum root, pinellia tuber, scutellaria root, jujube fruit, ginseng root, glycyrrhiza root, and ginger rhizome) was administered from 6 weeks of age until the rats were sacrificed at 76 weeks of age, at which time most of the nontreated animals were known to have hepatocellular carcinoma (HCC). Development of HCC in treated groups was analyzed histologically by comparison with untreated controls. Glutathione S-transferase placental form (GST-P) was analyzed by an immunohistochemical method. Concentration of copper, iron, and zinc, which appear to play a role in hepatocarcinogenesis in LEC rats, was analyzed The percent areas of HCC in the liver specimens of control, lycopene, and TJ-9 groups were 17.9 +/- 17.1%, 27.2 +/- 20.8%, and 27.6 +/- 18.4%, respectively. These intergroup differences were not significant. The percent area, number of areas, and mean size of area staining positively for GST-P revealed no significant differences between the groups. The number of GST-P-positive areas within the HCC lesions was greater in the TJ-9 group than in the control or lycopene group (p = 0.024 and p = 0.012, respectively). The study also demonstrated a lower concentration of iron in livers of the lycopene group than the control group (p = 0.019). There were no differences in serum a-fetoprotein levels or the cumulative survival rates between the groups. In conclusion, long-term administration of lycopene or TJ-9 did not reduce the risk of hepatocarcinogenesis in LEC rats.
• Studies in the Bicyclo[2.2.1]heptane Series. V. Reactions of Bicyclo[2.2.1]heptadiene¹
  作者：GEORGE T. YOUNGBLOOD、C. D. TRIVETTE、PELHAM WILDER

  DOI：10.1021/jo01099a011

  日期：1958.5
• Some Reactions of 2,5-Norbornadiene (Bicyclo[2.2.1]-2,5-heptadiene)¹
  作者：Louis Schmerling、J. P. Luvisi、Robert W. Welch

  DOI：10.1021/ja01593a047

  日期：1956.6
• US2730548
  申请人：——

  公开号：——

  公开（公告）日：——