| 1363444-66-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1363444-66-9
• 化学式: C₃₃H₅₂N₆O₂₁
• 分子量: 868.803
• InChiKey: QZQGFLLJGVGYBG-WINXUDPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.95
• 重原子数：
  60.0
• 可旋转键数：
  20.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  431.17
• 氢给体数：
  14.0
• 氢受体数：
  23.0

反应信息

• 作为反应物：
  描述：

  WSDBCO-BIOTIN,DBCO-SULFO-LINK-BIOTIN,磺基-二苯并环辛炔-生物素共轭物 、 在 尿素 作用下， 反应 3.0h， 生成
  参考文献：
  名称：

  Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers

  摘要：

  The disaccharide motif fucose-alpha(1-2)-galactose (Fuc alpha(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis. However, the size and structural complexity of Fuc alpha(1-2) Gal-containing glycans have posed a significant challenge to their detection. We report a new chemoenzymatic strategy for the rapid, sensitive detection of Fuc alpha(1-2)Gal glycans. We demonstrate that the approach is highly selective for the Fuc alpha(1-2)Gal motif, detects a variety of complex glycans and glycoproteins, and can be used to profile the relative abundance of the motif on live cells, discriminating malignant from normal cells. This approach represents a new potential strategy for biomarker detection and expands the technologies available for understanding the roles of this important class of carbohydrates in physiology and disease.

  DOI：

  10.1021/ja211312u
• 作为产物：
  描述：

  4-硝基苄胺 在 recombinant human blood group A antigen glycosyltransferase 、 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 二甲基亚砜 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers

  摘要：

  The disaccharide motif fucose-alpha(1-2)-galactose (Fuc alpha(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis. However, the size and structural complexity of Fuc alpha(1-2) Gal-containing glycans have posed a significant challenge to their detection. We report a new chemoenzymatic strategy for the rapid, sensitive detection of Fuc alpha(1-2)Gal glycans. We demonstrate that the approach is highly selective for the Fuc alpha(1-2)Gal motif, detects a variety of complex glycans and glycoproteins, and can be used to profile the relative abundance of the motif on live cells, discriminating malignant from normal cells. This approach represents a new potential strategy for biomarker detection and expands the technologies available for understanding the roles of this important class of carbohydrates in physiology and disease.

  DOI：

  10.1021/ja211312u