7-(4-hydroxyphenyl)-10,10-dimethyl-7,10,11,12-tetrahydro-6H-chromeno[4,3-b]quinoline-6,8(9H)-dione | 1372100-55-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(4-hydroxyphenyl)-10,10-dimethyl-7,10,11,12-tetrahydro-6H-chromeno[4,3-b]quinoline-6,8(9H)-dione
• 英文别名: 7-(4-hydroxy-phenyl)-10,10-dimethyl-7,10,11,12-tetrahydro-9H-chromeno[4,3-b]quinoline-6,8-dione；10,10-dimethyl-7-(4-hydroxyphenyl)-7,10,11,12-tetrahydro-9H-chromeno[4,3-b]quinoline-6,8-dione；7-(4-Hydroxyphenyl)-10,10-dimethyl-7,9,11,12-tetrahydrochromeno[4,3-b]quinoline-6,8-dione；7-(4-hydroxyphenyl)-10,10-dimethyl-7,9,11,12-tetrahydrochromeno[4,3-b]quinoline-6,8-dione
• CAS: 1372100-55-4
• 化学式: C₂₄H₂₁NO₄
• 分子量: 387.435
• InChiKey: VYSGEKBDJLYXAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  29
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 5.8h， 生成 7-(4-hydroxyphenyl)-10,10-dimethyl-7,10,11,12-tetrahydro-6H-chromeno[4,3-b]quinoline-6,8(9H)-dione
  参考文献：
  名称：

  An Efficient One-Pot Three-Component Synthesis of Highly Functionalized Coumarin Fused Indenodihydropyridine and Chromeno[4,3-b]quinoline Derivatives

  摘要：

  An efficient one-pot, three-component synthesis method of highly functionalized coumarin fused 7,13-dihydro-5-oxa-13-aza-indeno[2,1-b]phenanthrene and chromeno[4,3-b]quinoline derivatives was accomplished using aromatic aldehyde, 4-aminocoumarin and cyclic 1,3-dione in acetic acid at reflux temperature. Environmental-friendly protocol has advantages of high yields, creating three new bonds and one stereocenter in single operation. Further, XRD and DFT study confirmed the molecular structure, stability and different interaction in the crystal packing.

  DOI：

  10.3987/com-12-12494

文献信息

• Nicotinic acid‐supported cobalt ferrite‐catalyzed one‐pot synthesis of substituted chromeno[3,4‐ <i>b</i> ]quinolines
  作者：Mahdiye Foroughi Kaldareh、Masoud Mokhtary、Mohammad Nikpassand

  DOI：10.1002/aoc.5469

  日期：2020.4

  One‐pot synthesis of substituted chromeno[3,4‐b]quinoline derivatives was developed by three‐component reaction of aldehydes, dimedone or 1,3‐cyclohexadione, and 4‐aminocoumarin in the presence of nicotinic acid‐supported cobalt ferrite [CoFe2O4@SiO2@Si(CH2)3Cl@NA] as a novel magnetic catalyst in chloroform at reflux conditions. Nicotinic acid‐supported cobalt ferrite was characterized via Fourier

  在烟酸支持的钴铁氧体[CoFe]存在下，通过醛，二甲酮或1,3-环己二酮和4-氨基香豆素的三组分反应，开发了取代的铬诺[3,4- b ]喹啉衍生物的一锅法合成方法。2 O 4 @SiO 2 @Si（CH 2）3Cl @ NA]作为一种新型的磁性催化剂在氯仿中回流条件下。烟酸负载的钴铁氧体通过傅里叶变换红外光谱，X射线衍射，热重分析，扫描电子显微镜，高分辨率透射电子显微镜，能量色散X射线光谱和振动样品磁强分析进行了表征。而且，该催化剂可以容易地通过磁分离回收并循环多达五次而不会显着降低其催化活性。在环境友好的条件下，经过适当的反应时间，生成的产品产率极高。该方法的显着优点是具有高效率，并且通过简单的磁引力容易将催化剂从产物中分离出来。
• Novel marine‐based gold nanocatalyst in solvent‐free synthesis of polyhydroquinoline derivatives: Green and sustainable protocol
  作者：Mahsa Sepahvand、Foad Buazar、Mohammad Hosein Sayahi

  DOI：10.1002/aoc.6000

  日期：2020.12

  11 ± 1.5 nm in transmission electron microscopy (TEM) and exhibited a crystal structure of face‐centered cubic in X‐ray diffraction (XRD) analyses. Our results indicated that bioinspired AuNPs demonstrate superior catalytic activity in the safe and facile one‐pot synthesis of polyhydroquinoline derivatives under solvent‐free reaction conditions. This green route encompasses multiple benefits including

  我们报告了一种环保的合成方法，该方法利用富电子海参提取物作为生物还原剂和稳定剂，在最佳条件下将金阳离子还原为AuNPs，从而制备生物金纳米颗粒（AuNPs）。所产生的AuNP呈球形，在透射电子显微镜（TEM）中的平均粒径为11±1.5 nm，并且在X射线衍射（XRD）分析中显示出面心立方的晶体结构。我们的结果表明，在无溶剂的反应条件下，以生物为灵感的AuNPs在安全，便捷的一锅法合成多氢喹啉衍生物中显示出优异的催化活性。这条绿色路线包含多项优势，包括可高度循环利用的生物启发催化剂（5个循环），较短的反应时间，方便的锻炼，
• An efficient green protocol for the synthesis of coumarin fused highly decorated indenodihydropyridyl and dihydropyridyl derivatives
  作者：Sanjay Paul、Asish R. Das

  DOI：10.1016/j.tetlet.2012.02.077

  日期：2012.4

  A simple, convenient, environmentally benign, and mild synthetic method has been established to afford highly decorated indenodihydropyridine and dihydropyridine derivatives employing a green solvent ethyl-L-lactate and an organo-catalyst (+/-)lactic acid. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in moderate to good yields applying the current method. (c) 2012 Elsevier Ltd. All rights reserved.