10,10-dimethyl-7-(4-nitro-phenyl)-7,10,11,12-tetrahydro-9H-chromeno[4,3-b]quinoline-6,8-dione | 1372100-49-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10,10-dimethyl-7-(4-nitro-phenyl)-7,10,11,12-tetrahydro-9H-chromeno[4,3-b]quinoline-6,8-dione
• 英文别名: 10,10-dimethyl-7-(3-nitrophenyl)-7,10,11,12-tetrahydro-9H-chromeno[4,3-b]quinoline-6,8-dione；10,10-Dimethyl-7-(4-nitrophenyl)-7,9,11,12-tetrahydrochromeno[4,3-b]quinoline-6,8-dione；10,10-dimethyl-7-(4-nitrophenyl)-7,9,11,12-tetrahydrochromeno[4,3-b]quinoline-6,8-dione
• CAS: 1372100-49-6
• 化学式: C₂₄H₂₀N₂O₅
• 分子量: 416.433
• InChiKey: CLWXWEGCIXEVMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟基香豆素 在 ammonium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 5.7h， 生成 10,10-dimethyl-7-(4-nitro-phenyl)-7,10,11,12-tetrahydro-9H-chromeno[4,3-b]quinoline-6,8-dione
  参考文献：
  名称：

  An Efficient One-Pot Three-Component Synthesis of Highly Functionalized Coumarin Fused Indenodihydropyridine and Chromeno[4,3-b]quinoline Derivatives

  摘要：

  An efficient one-pot, three-component synthesis method of highly functionalized coumarin fused 7,13-dihydro-5-oxa-13-aza-indeno[2,1-b]phenanthrene and chromeno[4,3-b]quinoline derivatives was accomplished using aromatic aldehyde, 4-aminocoumarin and cyclic 1,3-dione in acetic acid at reflux temperature. Environmental-friendly protocol has advantages of high yields, creating three new bonds and one stereocenter in single operation. Further, XRD and DFT study confirmed the molecular structure, stability and different interaction in the crystal packing.

  DOI：

  10.3987/com-12-12494

文献信息

• Novel marine‐based gold nanocatalyst in solvent‐free synthesis of polyhydroquinoline derivatives: Green and sustainable protocol
  作者：Mahsa Sepahvand、Foad Buazar、Mohammad Hosein Sayahi

  DOI：10.1002/aoc.6000

  日期：2020.12

  11 ± 1.5 nm in transmission electron microscopy (TEM) and exhibited a crystal structure of face‐centered cubic in X‐ray diffraction (XRD) analyses. Our results indicated that bioinspired AuNPs demonstrate superior catalytic activity in the safe and facile one‐pot synthesis of polyhydroquinoline derivatives under solvent‐free reaction conditions. This green route encompasses multiple benefits including

  我们报告了一种环保的合成方法，该方法利用富电子海参提取物作为生物还原剂和稳定剂，在最佳条件下将金阳离子还原为AuNPs，从而制备生物金纳米颗粒（AuNPs）。所产生的AuNP呈球形，在透射电子显微镜（TEM）中的平均粒径为11±1.5 nm，并且在X射线衍射（XRD）分析中显示出面心立方的晶体结构。我们的结果表明，在无溶剂的反应条件下，以生物为灵感的AuNPs在安全，便捷的一锅法合成多氢喹啉衍生物中显示出优异的催化活性。这条绿色路线包含多项优势，包括可高度循环利用的生物启发催化剂（5个循环），较短的反应时间，方便的锻炼，
• Electrochemical synthesis of three‐dimensional flower‐like Ni/Co–BTC bimetallic organic framework as heterogeneous catalyst for solvent‐free and green synthesis of substituted chromeno[4,3– <i>b</i> ]quinolones
  作者：Mohammad Hosein Sayahi、Matineh Ghomi、Samir M. Hamad、Mohammad Reza Ganjali、Mustafa Aghazadeh、Mohammad Mahdavi、Saeed Bahadorikhalili

  DOI：10.1002/jccs.202000314

  日期：2021.4

  energy dispersive X‐ray analysis (EDX). The catalytic activity of the resulting Ni/Co is evaluated in a one‐pot four‐component reaction of dimedone, aromatic aldehyde, 4–hydroxycoumarin, and ammonium acetate for the synthesis of chromeno[4,3–b]quinolone derivatives under solvent‐free condition. The Ni/Co–BTC BMOF catalyst showed very good activity in the tested reaction, and a wide scope of starting

  在这项研究中，通过阴极电合成（CE）方法合成了一种新的花状Ni 0.77 / Co 0.23 –苯–1,3,5-三羧酸盐（BTC）双金属有机骨架（Ni / Co–BTC BMOF）。在镍和钴金属以及BTC连接器上。合成的BMOF具有多种方法，包括傅里叶变换红外光谱（FT-IR），粉末X射线衍射（PXRD），场发射扫描电子显微镜（FE-SEM）和能量色散X射线分析（EDX） 。在二锅酮，芳醛，4-羟基香豆素和乙酸铵的一锅四组分反应中，对合成的铬色素[4,3- b]进行了评估，评估了生成的Ni / Co的催化活性。无溶剂条件下的]喹诺酮衍生物。Ni / Co-BTC BMOF催化剂在测试的反应中显示出非常好的活性，在Ni / Co-BTC BMOF催化剂的存在下，多种原料以高分离产率提供了所需的产物。Ni / Co BMOF的回收是通过离心机实现的，可重复使用至少六次，而催化活性不会显着降低。
• An efficient green protocol for the synthesis of coumarin fused highly decorated indenodihydropyridyl and dihydropyridyl derivatives
  作者：Sanjay Paul、Asish R. Das

  DOI：10.1016/j.tetlet.2012.02.077

  日期：2012.4

  A simple, convenient, environmentally benign, and mild synthetic method has been established to afford highly decorated indenodihydropyridine and dihydropyridine derivatives employing a green solvent ethyl-L-lactate and an organo-catalyst (+/-)lactic acid. A wide range of functional groups were tolerated in the developed protocol. The target molecules were obtained in moderate to good yields applying the current method. (c) 2012 Elsevier Ltd. All rights reserved.
• An Efficient One-Pot Three-Component Synthesis of Highly Functionalized Coumarin Fused Indenodihydropyridine and Chromeno[4,3-b]quinoline Derivatives
  作者：Naseem Ahmed、B. Venkata Babu、Sandeep Singh、Petar M. Mitrasinovic

  DOI：10.3987/com-12-12494

  日期：——

  An efficient one-pot, three-component synthesis method of highly functionalized coumarin fused 7,13-dihydro-5-oxa-13-aza-indeno[2,1-b]phenanthrene and chromeno[4,3-b]quinoline derivatives was accomplished using aromatic aldehyde, 4-aminocoumarin and cyclic 1,3-dione in acetic acid at reflux temperature. Environmental-friendly protocol has advantages of high yields, creating three new bonds and one stereocenter in single operation. Further, XRD and DFT study confirmed the molecular structure, stability and different interaction in the crystal packing.