tert-butyl N-[1-[tert-butyl(dimethyl)silyl]oxy-3-(2-hydroxy-4,6-dimethylphenyl)-3-methylbutan-2-yl]carbamate | 1032401-02-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[1-[tert-butyl(dimethyl)silyl]oxy-3-(2-hydroxy-4,6-dimethylphenyl)-3-methylbutan-2-yl]carbamate
• CAS: 1032401-02-7
• 化学式: C₂₄H₄₃NO₄Si
• 分子量: 437.695
• InChiKey: DXBMXMNIAHVEEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[1-[tert-butyl(dimethyl)silyl]oxy-3-(2-hydroxy-4,6-dimethylphenyl)-3-methylbutan-2-yl]carbamate 在 sodium chlorite 、 sodium dihydrogenphosphate 、 2-甲基-2-丁烯 、 potassium carbonate 、 溶剂黄146 、 pyridinium chlorochromate 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 丙酮 、 叔丁醇 为溶剂， 反应 31.0h， 生成 3-[2-(4,5-dimethoxy-2-nitrobenzyloxy)-4,6-dimethylphenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutyric acid
  参考文献：
  名称：

  Polymer Nanoparticles Modified with Photo- and pH-Dual-Responsive Polypeptides for Enhanced and Targeted Cancer Therapy

  摘要：

  The cationic nature of cell penetrating peptides (CPPs) and their absence of cell selectivity restrains their applications in vivo. In this work, polymer nanoparticles (NPs) modified with photo- and pH-responsive polypeptides (PPPs) were successfully developed and respond to near-infrared (NIR) light illumination at the tumor site and a lowered tumor extracellular pH (pHe). In PPPs, the internalization function of CPPs (positively charged) is quenched by a pH-sensitive inhibitory peptide (negatively charged), which is linked via a photocleavable group. Small interfering RNA (siRNA) was loaded into NPs by a double-emulsion technique. In vivo experiments included siRNA loading, cellular uptake, cell apoptosis, siRNA transfection, tumor targeting delivery, and the in vivo antitumor efficacy. Results showed that the prepared PPP-NPs could selectively accumulate at the tumor sites and internalized into the tumor cells by the NIR light illumination and the lowered pHe at the tumor site. These studies demonstrated that PPP-NPs are a promising carrier for future tumor gene delivery.

  DOI：

  10.1021/acs.molpharmaceut.5b00977

文献信息

• Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system
  作者：Akira Shigenaga、Jun Yamamoto、Hiroko Hirakawa、Keiji Ogura、Nami Maeda、Ko Morishita、Akira Otaka

  DOI：10.1016/j.tetlet.2010.03.006

  日期：2010.5

  To develop a thiol-responsive DNA-releasing system, a thiol-responsive amino acid capable of inducing an amide bond cleavage in the presence of a thiol was developed. It was successfully combined with peptide nucleic acid (PNA), and thiol-induced release of DNA from the thiol-responsive PNA/DNA complex was observed.

  为了开发硫醇响应性DNA释放系统，开发了能够在硫醇存在下诱导酰胺键裂解的硫醇响应性氨基酸。它已成功与肽核酸（PNA）结合，并观察到巯基诱导的DNA从巯基响应性PNA / DNA复合物中的释放。
• Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation-responsive peptide
  作者：Akira Shigenaga、Jun Yamamoto、Yoshitake Sumikawa、Toshiaki Furuta、Akira Otaka

  DOI：10.1016/j.tetlet.2010.03.079

  日期：2010.5

  Two-photon near-infrared excitation-responsive amino acid was developed. It was incorporated into a peptide, and focused near-infrared pulsed laser irradiation-induced peptide bond cleavage reaction at the C-terminal position of the photo-responsive amino acid was observed.

  开发了双光子近红外激发响应型氨基酸。将其掺入肽中，并在光响应性氨基酸的C-末端位置聚焦近红外脉冲激光辐照诱导的肽键裂解反应。
• Polymer Nanoparticles Modified with Photo- and pH-Dual-Responsive Polypeptides for Enhanced and Targeted Cancer Therapy
  作者：Yang Yang、Xiangyang Xie、Yanfang Yang、Zhiping Li、Fanglin Yu、Wei Gong、Ying Li、Hui Zhang、Zhiyuan Wang、Xingguo Mei

  DOI：10.1021/acs.molpharmaceut.5b00977

  日期：2016.5.2

  The cationic nature of cell penetrating peptides (CPPs) and their absence of cell selectivity restrains their applications in vivo. In this work, polymer nanoparticles (NPs) modified with photo- and pH-responsive polypeptides (PPPs) were successfully developed and respond to near-infrared (NIR) light illumination at the tumor site and a lowered tumor extracellular pH (pHe). In PPPs, the internalization function of CPPs (positively charged) is quenched by a pH-sensitive inhibitory peptide (negatively charged), which is linked via a photocleavable group. Small interfering RNA (siRNA) was loaded into NPs by a double-emulsion technique. In vivo experiments included siRNA loading, cellular uptake, cell apoptosis, siRNA transfection, tumor targeting delivery, and the in vivo antitumor efficacy. Results showed that the prepared PPP-NPs could selectively accumulate at the tumor sites and internalized into the tumor cells by the NIR light illumination and the lowered pHe at the tumor site. These studies demonstrated that PPP-NPs are a promising carrier for future tumor gene delivery.