N'-(4-fluorophenyl)-2-oxo-N-(quinolin-8-yl)propanehydrazonamide | 1079363-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N'-(4-fluorophenyl)-2-oxo-N-(quinolin-8-yl)propanehydrazonamide
• CAS: 1079363-96-4
• 化学式: C₁₈H₁₅FN₄O
• 分子量: 322.342
• InChiKey: RKZVXPHJXQCSHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.38
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N'-(4-fluorophenyl)-2-oxo-N-(quinolin-8-yl)propanehydrazonamide 在 copper(II) choride dihydrate 作用下， 以 乙醇 为溶剂， 以22%的产率得到1-[1,4-Bis(4-fluorophenyl)pyrido[2,3-f][1,2,4]benzotriazin-2-yl]ethanone
  参考文献：
  名称：

  Khanfar, Monther A.; Abu Thaher, Bassam A.; Zahra, Jalal A., Zeitschrift fur Naturforschung, B: Chemical Sciences, 2008, vol. 63, # 9, p. 1107 - 1111

  摘要：

  DOI：
• 作为产物：
  描述：

  8-氨基喹啉 、 N-(4-fluorophenyl)-2-oxopropanehydrazonoyl chloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以40%的产率得到N'-(4-fluorophenyl)-2-oxo-N-(quinolin-8-yl)propanehydrazonamide
  参考文献：
  名称：

  Khanfar, Monther A.; Abu Thaher, Bassam A.; Zahra, Jalal A., Zeitschrift fur Naturforschung, B: Chemical Sciences, 2008, vol. 63, # 9, p. 1107 - 1111

  摘要：

  DOI：

文献信息

• Azoimine quinoline derivatives: Synthesis, classical and electrochemical evaluation of antioxidant, anti-inflammatory, antimicrobial activities and the DNA / BSA binding
  作者：Khaoula Douadi、Salah Chafaa、Tahar Douadi、Mousa Al-Noaimi、Ilhem Kaabi

  DOI：10.1016/j.molstruc.2020.128305

  日期：2020.10

  concentrations, the four compounds showed a greater antioxidant potential than that of ascorbic acid. The results of the antimicrobial screening indicate that all derivatives have a variable activity against the investigated species, bacteria and fungi. The anti-inflammatory activity of the compounds was found to be in the range of 55–80%. The binding interaction of these molecules with DNA and bovine

  摘要 四种偶氮亚胺喹啉衍生物，即 (1Z)-N'-(4-fluorophenyl)-2-oxo-N-quinolin-8-ylpropanehydrazonamide(H2L-F),(1Z)-2-oxo-N'-phenyl-N -quinolin-8-ylpropane hydrazonamide(H2L-H),(1Z)-N'-(4-nitrophenyl)-2-oxo-N-quinolin-8-ylpropane hydrazonamide(H2L-NO2) 和 (1Z)-N' -(4-溴苯基)-2-oxo-N-quinolin-8-ylpropane hydrazonamide (H2L-Br) 被合成并评估其生物活性。在非常低的浓度下，这四种化合物显示出比抗坏血酸更大的抗氧化潜力。抗菌筛选的结果表明，所有衍生物对所研究的物种、细菌和真菌具有不同的活性。发现这些化合物的抗炎活性在 55-80%
• Synthesis, X-ray structure, spectroscopic, DFT study and catalytic activity of cis-[RuCl2(L)(EPh3)] complexes (E = P, As, Sb; L = NN′N″ tridentate azoimine-quinoline ligands)
  作者：Mousa Al-Noaimi、Ayman Hammoudeh、Firas F. Awwadi、Raja Bader、Amal Mahmoud

  DOI：10.1016/j.ica.2017.10.033

  日期：2018.2

  New of complexes of formula cis-[RuCl2(L)(PPh3)] (C1-C5) where L = XC6H4N=NC(COCH3)=NC9H6N, X = H, L1 (C1); CH3, L2 (C2); Br, L3 (C3); CN, L4 (C4), F, L5 (C5)} and cis-[RuCl2(L1)(EPh3)] where E = As (C6); E = Sb (C7) have been synthesized by refluxing [RuCl2(EPh3)(3)] and L in a mixture of (5:1) chloroform/ethanol solution. The complexes have been characterized by the spectroscopic techniques (IR, NMR and UV-Vis) and geometries have been confirmed by X-ray crystal structures of cis-[RuCl2(L3)(PPh3)] (C3). The electronic structure, redox and absorption properties of the complexes have been explained based on DFT and TDDFT results. Cyclic voltammetric studies show one reversible Ru(III)/Ru(II) oxidation couple and two successive one electron reductions leading to the formation of L(0/-1) and L(-1/-2), respectively. The complexes cis-[RuCl2(L)(EPh3)](C1-C7) catalyze the transfer hydrogenation of acetophenone in 2-propanol at 86 degrees C and in the presence NaOCH3. (C) 2017 Elsevier B.V. All rights reserved.