4-acetyl-2',5'-bis(tert-butyldimethylsilyloxy)-4'-methoxybiphenyl | 1000792-31-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetyl-2',5'-bis(tert-butyldimethylsilyloxy)-4'-methoxybiphenyl
• 英文别名: 1-[4-[2,5-Bis[[tert-butyl(dimethyl)silyl]oxy]-4-methoxyphenyl]phenyl]ethanone；1-[4-[2,5-bis[[tert-butyl(dimethyl)silyl]oxy]-4-methoxyphenyl]phenyl]ethanone
• CAS: 1000792-31-3
• 化学式: C₂₇H₄₂O₄Si₂
• 分子量: 486.799
• InChiKey: TVPSAJIMOGENQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.33
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[2,5-bis(tert-butyldimethylsilyloxy)-4-methoxyphenyl]-4,4,5,5-tetramethyl[1,3,2]dioxaborolane 、 4-溴苯乙酮 在 trans-PdBr(N-Succ)(PPh₃)2 sodium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 15.0h， 以84%的产率得到4-acetyl-2',5'-bis(tert-butyldimethylsilyloxy)-4'-methoxybiphenyl
  参考文献：
  名称：

  Simple Palladium(II) Precatalyst for Suzuki−Miyaura Couplings:  Efficient Reactions of Benzylic, Aryl, Heteroaryl, and Vinyl Coupling Partners

  摘要：

  trans-PdBr(N-Succ)(PPh3)(2) (1) is a universally effective precatalyst for Suzuki-Miyaura cross-couplings of benzylic halides with aryl- or heteroarylboronic acids. Substituted aryl halides and halogenated cyclic enones can be cross-coupled with aryl- or vinylboronic acids in excellent yields. Catalyst recycling is also demonstrated.

  DOI：

  10.1021/ol702291r

文献信息

• Simple Palladium(II) Precatalyst for Suzuki−Miyaura Couplings:  Efficient Reactions of Benzylic, Aryl, Heteroaryl, and Vinyl Coupling Partners
  作者：Michael J. Burns、Ian J. S. Fairlamb、Anant R. Kapdi、Petr Sehnal、Richard J. K. Taylor

  DOI：10.1021/ol702291r

  日期：2007.12.1

  trans-PdBr(N-Succ)(PPh3)(2) (1) is a universally effective precatalyst for Suzuki-Miyaura cross-couplings of benzylic halides with aryl- or heteroarylboronic acids. Substituted aryl halides and halogenated cyclic enones can be cross-coupled with aryl- or vinylboronic acids in excellent yields. Catalyst recycling is also demonstrated.