2-FMOC-氨基-3-苯基丁酸 | 1214028-21-3

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 2-FMOC-氨基-3-苯基丁酸
• 英文名称: 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylbutanoic acid
• 英文别名: Fmoc-beta-methyl-DL-phenylalanine；2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylbutanoic acid
• CAS: 1214028-21-3
• 化学式: C₂₅H₂₃NO₄
• 分子量: 401.462
• InChiKey: ZQWJZRLWGALBIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为反应物：
  描述：

  2-FMOC-氨基-3-苯基丁酸 在 盐酸 、 sodium carbonate 作用下， 以 水 、 丙酮 为溶剂， 反应 2.0h， 生成 2-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile

  摘要：

  DOI：

  10.1021/acs.jmedchem.0c01941
• 作为产物：
  描述：

  beta-甲基-苯丙氨酸 、 9-芴甲基-N-琥珀酰亚胺基碳酸酯 在 sodium carbonate 作用下， 以 水 、 丙酮 为溶剂， 生成 2-FMOC-氨基-3-苯基丁酸
  参考文献：
  名称：

  Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile

  摘要：

  DOI：

  10.1021/acs.jmedchem.0c01941

文献信息

• Methods and compositions using Substance P to promote wound healing
  申请人：Reid Ted

  公开号：US20070154448A1

  公开（公告）日：2007-07-05

  Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include tachykinins, such as Substance P, Substance K, and the like, as well as calcitonin gene-related peptides. The compositions may further include a polymeric delivery carrier and are utilized by applying to the site of the wound. Wounds may be vascular or avascular wounds. The compositions promote elaboration of cellular matrices and development of cellular attachment mechanisms in addition to stimulating cellular proliferation.
• METHODS AND COMPOSITIONS USING SUBSTANCE P TO PROMOTE WOUND HEALING
  申请人：Reid Ted

  公开号：US20100092561A1

  公开（公告）日：2010-04-15

  Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include tachykinins, such as Substance P, Substance K, and the like, as well as calcitonin gene-related peptides. The compositions may further include a polymeric delivery carrier and are utilized by applying to the site of the wound. Wounds may be vascular or avascular wounds. The compositions promote elaboration of cellular matrices and development of cellular attachment mechanisms in addition to stimulating cellular proliferation.
• US8222210B2
  申请人：——

  公开号：US8222210B2

  公开（公告）日：2012-07-17
• [EN] METHODS AND COMPOSITIONS USING SUBSTANCE P TO PROMOTE WOUND HEALING<br/>[FR] METHODES ET COMPOSITIONS FAISANT APPEL A UNE SUBSTANCE P POUR FAVORISER LA CICATRISATION DE LESIONS
  申请人：REID TED

  公开号：WO2007062060A2

  公开（公告）日：2007-05-31

  [EN] Healing of wounds in mammalian tissue may be enhanced by the application of certain neuropeptides, optionally in combination with known growth promoting hormones. Exemplary neuropeptides include tachykinins, such as Substance P, Substance K, and the like, as well as calcitonin gene-related peptides. The compositions may further include a polymeric delivery carrier and are utilized by applying to the site of the wound. Wounds may be vascular or avascular wounds. The compositions promote elaboration of cellular matrices and development of cellular attachment mechanisms in addition to stimulating cellular proliferation.
  [FR] La cicatrisation de lésions au niveau de tissus de mammifères peut être améliorée par l'application de certains neuropeptides, éventuellement en combinaison avec des hormones connues favorisant la croissance. Parmi les exemples de neuropeptides, on trouve des tachykinines, comme la substance P, la substance K et analogues, ainsi que des peptides liés au gène de la calcitonine. Lesdites compositions peuvent également comprendre un vecteur polymère et sont utilisés par application sur le site de la lésion. Les lésions peuvent être des lésions vasculaires ou avasculaires. Lesdites compositions favorisent l'élaboration de matrices cellulaires et le développement de mécanismes de fixation cellulaire en plus de stimuler la prolifération cellulaire.