7-aminoprocaterol hydrochloride | 66283-47-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-aminoprocaterol hydrochloride
• CAS: 66283-47-4
• 化学式: C₁₆H₂₃N₃O₃*ClH
• 分子量: 341.838
• InChiKey: YPVQRRVXDQRKAE-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  7-aminoprocaterol hydrochloride 在 钯 氢氧化钾 、 氢气 作用下， 反应 21.0h， 生成 7-amino-5-<1-hydroxy-2-(isopropylamino)butyl>carbostyril
  参考文献：
  名称：

  Erythro-5-[1-hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril, a terbutaline-type derivative of the bronchodilator procaterol

  摘要：

  erythro-5-[1-Hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril (4), which is a terbutaline-type derivative of the bronchodilator procaterol, was synthesized by transfer of the 8-hydroxyl group of procaterol to the 7 position. Compound 4 showed less potent beta-adrenoceptor stimulant activities than procaterol or terbutaline in an in vitro test using guinea pig tracheal muscle and right atrium. In an in vivo assay on anesthetized dogs, compound 4 showed 42 times less bronchodilator activity and 87 times less effect on the heart rate than l-isoproterenol.

  DOI：

  10.1021/jm00137a030
• 作为产物：
  描述：

  7-nitroprocaterol hydrochloride 在 钯 氢气 作用下， 以 水 为溶剂， 反应 3.0h， 以49%的产率得到7-aminoprocaterol hydrochloride
  参考文献：
  名称：

  Erythro-5-[1-hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril, a terbutaline-type derivative of the bronchodilator procaterol

  摘要：

  erythro-5-[1-Hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril (4), which is a terbutaline-type derivative of the bronchodilator procaterol, was synthesized by transfer of the 8-hydroxyl group of procaterol to the 7 position. Compound 4 showed less potent beta-adrenoceptor stimulant activities than procaterol or terbutaline in an in vitro test using guinea pig tracheal muscle and right atrium. In an in vivo assay on anesthetized dogs, compound 4 showed 42 times less bronchodilator activity and 87 times less effect on the heart rate than l-isoproterenol.

  DOI：

  10.1021/jm00137a030