| 1075227-44-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1075227-44-9
• 化学式: C₄₅H₄₇NO₇
• 分子量: 713.871
• InChiKey: DDWRYOBLFXHWKK-KNEQNCEGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.58
• 重原子数：
  53.0
• 可旋转键数：
  14.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  75.69
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 palladium dihydroxide 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以99.3%的产率得到(4S,6R,8R,9S,10S,11R)-9,10,11-trihydroxy-8-(hydroxymethyl)-3-methyl-4-(4-methylphenyl)-1,7-dioxa-3-azaspiro[5.5]undecan-2-one
  参考文献：
  名称：

  Stereoselective synthesis and biological activity of novel spiro-oxazinanone-C-glycosides

  摘要：

  The stereoselective synthesis of novel spiro-oxazinanone nucleosides 9 and 10 has been achieved by microwave assisted 1,3-dipolar cycloaddition of exo-glucal (1) and nitrones (2), and followed by reduction, stereospecific recyclization, and catalytic deprotection. The structures of the spironucleosides were determined according to the H-1 NMR, C-13 NMR, 2D NMR, MS, and X-ray analyses, and the biological activities of the title compounds against glycosidases (alpha-amylase, alpha-glucosidase, and beta-glucosidase) and cytotoxicity were also evaluated. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.002
• 作为产物：
  描述：

  三光气 、 (3S,5R,7R,8R,9S,10R)-8,9,10-tris(benzyloxy)-7-((benzyloxy)methyl)-2-methyl-3-(p-tolyl)-1,6-dioxa-2-azaspiro[4.5]decane 在 溶剂黄146 、 锌 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  Stereoselective synthesis and biological activity of novel spiro-oxazinanone-C-glycosides

  摘要：

  The stereoselective synthesis of novel spiro-oxazinanone nucleosides 9 and 10 has been achieved by microwave assisted 1,3-dipolar cycloaddition of exo-glucal (1) and nitrones (2), and followed by reduction, stereospecific recyclization, and catalytic deprotection. The structures of the spironucleosides were determined according to the H-1 NMR, C-13 NMR, 2D NMR, MS, and X-ray analyses, and the biological activities of the title compounds against glycosidases (alpha-amylase, alpha-glucosidase, and beta-glucosidase) and cytotoxicity were also evaluated. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.002