7-(((3-methylpyridin-2-yl)amino)(phenyl)methyl)quinolin-8-ol | 73855-36-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(((3-methylpyridin-2-yl)amino)(phenyl)methyl)quinolin-8-ol
• 英文别名: 7-[α-(3-methyl-[2]pyridylamino)-benzyl]-quinolin-8-ol；7-[α-(3-Methyl-[2]pyridylamino)-benzyl]-chinolin-8-ol；7-(alpha-(3-Methyl-2-pyridylamino)benzyl)-8-quinolinol；7-[[(3-methylpyridin-2-yl)amino]-phenylmethyl]quinolin-8-ol
• CAS: 73855-36-4
• 化学式: C₂₂H₁₉N₃O
• 分子量: 341.412
• InChiKey: WKQUEMVLENNTJC-UHFFFAOYSA-N

物化性质

• 沸点：
  554.5±45.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  58
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-3-甲基吡啶 、 8-羟基喹啉 、 苯甲醛 在 乙醇 作用下， 生成 7-(((3-methylpyridin-2-yl)amino)(phenyl)methyl)quinolin-8-ol
  参考文献：
  名称：

  THE REACTION OF ANILS WITH 8-QUINOLINOL

  摘要：

  DOI：

  10.1021/jo01371a005

文献信息

• METHODS OF TREATING CREATINE TRANSPORTER DEFICIENCY
  申请人：Jnana Therapeutics, Inc.

  公开号：US20210299070A1

  公开（公告）日：2021-09-30

  Disclosed are methods of treating creatine transporter deficiency, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that increases transport of a substrate by a mutant or wild-type creatine transporter. Also disclosed are methods of increasing transport of guanidinoacetic acid or a salt thereof across the blood-brain barrier of a mammal, and methods of decreasing accumulation or the concentration of guanidinoacetic acid or a salt thereof in a mammalian cell.

  揭示了治疗肌酸转运蛋白缺乏症的方法，包括向需要的哺乳动物施用增加突变型或野生型肌酸转运蛋白对底物转运的化合物的治疗有效量。还披露了增加鸟氨酸乙酸或其盐跨越哺乳动物血脑屏障的方法，以及减少哺乳动物细胞中鸟氨酸乙酸或其盐的积累或浓度的方法。
• SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS
  申请人：Jnana Therapeutics, Inc.

  公开号：US20210300898A1

  公开（公告）日：2021-09-30

  Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with a mutation in a protein.

  揭示了用于治疗或预防与蛋白质突变相关的疾病或紊乱的化合物、组合物和方法。
• [EN] METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS<br/>[FR] PROCÉDÉ POUR TRAITER DES INFECTIONS BACTÉRIENNES RÉSISTANT AU MÉDICAMENT ET D'AUTRES INFECTIONS PAR DU CLIOQUINOL, DE LA PHANQUINONE ET DES COMPOSÉS APPARENTÉS
  申请人：XILINAS MICHEL E

  公开号：WO2009140215A2

  公开（公告）日：2009-11-19

  The invention relates to new uses of known chelating compounds for the treatment of bacterial in fungal infections, particularly by methicilllin-resistant and other drug-resistant strains of bacteria and fungi. One of more chelating compound is administered with or without additional antibiotic or antifungal drugs to achieve improved therapy. Preferred chelating compounds include clioquinol, 5,7-dichloro-8-hydroxy-quinaldine, phanquinone, 5,7-dichloro-8-hydroxyquinoline, 5,7- di-iodo-8-hydroxyquinoline. By chelation of specific metal ions, these compounds treat any infection by bacteria or fungi whose pathogenicity depends upon metalloenzymes that require these cations. The compounds are also effective against infections caused by extended β lactamase and metallo β lactamase producing bacterial strains. Bacteria targeted by these methods include methicillin-resistant Staphylococcus aureus, penicillin resistant or intermediate resistant Streptococcus pneumoniae and other gram positive and multiresistant gram negative species and strains.
• [EN] SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS<br/>[FR] PETITES MOLÉCULES CIBLANT DES PROTÉINES MUTANTES DE MAMMIFÈRES
  申请人：JNANA THERAPEUTICS INC

  公开号：WO2020061476A1

  公开（公告）日：2020-03-26

  Disclosed are compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with mutation in a protein. One aspect of the invention provides compounds, compositions, and methods useful for treating or preventing a disease or disorder associated with a SLC6A8 mutation.
• THE REACTION OF ANILS WITH 8-QUINOLINOL
  作者：J. P. PHILLIPS、R. W. KEOWN、QUINTUS FERNANDO

  DOI：10.1021/jo01371a005

  日期：1954.6