11,13-dihydro-13-dimethylaminoparthenin | 133411-39-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 11,13-dihydro-13-dimethylaminoparthenin
• CAS: 133411-39-9
• 化学式: C₁₇H₂₅NO₄
• 分子量: 307.39
• InChiKey: YMRQZAAIPRJGON-DENOOXKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.01
• 重原子数：
  22.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  66.84
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  银胶菊宁 、 二甲胺 以 乙醇 为溶剂， 以400 mg的产率得到11,13-dihydro-13-dimethylaminoparthenin
  参考文献：
  名称：

  Antimalarial activity of parthenin and its derivatives

  摘要：

  Parthenin and some of its derivatives have been shown to posses significant anti-malarial activity against a multi-drug resistant strain of Plasmodium falciparum. Structure-activity relationships in this series of compounds are discussed and possible mechanisms of action considered. Molecular matching of the oxygen atoms of parthenin and the new anti-malarial drug qinghaosu shows both molecules to be amphipathic with common areas for their oxygen atoms and hydrocarbon frameworks.

  DOI：

  10.1016/0223-5234(90)90190-e

文献信息

• Bhonsle, J. B.; Kamath, H. V.; Nagasampagi, B. A., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1994, vol. 33, # 4, p. 391 - 392
  作者：Bhonsle, J. B.、Kamath, H. V.、Nagasampagi, B. A.、Ravindranathan, T.

  DOI：——

  日期：——