(7-chloro-[4]quinolyl)-heptyl-amine | 108977-01-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (7-chloro-[4]quinolyl)-heptyl-amine
• 英文别名: (7-Chlor-[4]chinolyl)-heptyl-amin；7-chloro-N-heptylquinolin-4-amine
• CAS: 108977-01-1
• 化学式: C₁₆H₂₁ClN₂
• 分子量: 276.809
• InChiKey: QHMKSJWTLFPGDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (7-chloro-[4]quinolyl)-heptyl-amine 在 氢氧化钾 、 palladium on activated charcoal 作用下， 生成 4-Heptylamino-chinolin
  参考文献：
  名称：

  Campbell; Cavalla, Journal of the Chemical Society, 1957, p. 4403

  摘要：

  DOI：
• 作为产物：
  描述：

  4,7-二氯喹啉 、 庚胺 生成 (7-chloro-[4]quinolyl)-heptyl-amine
  参考文献：
  名称：

  Campbell; Cavalla, Journal of the Chemical Society, 1957, p. 4403

  摘要：

  DOI：

文献信息

• Antimalarial Quinolines and Methods of Use Thereof
  申请人：Wolf Christian

  公开号：US20110045100A1

  公开（公告）日：2011-02-24

  One aspect of the invention relates to substitute quinolines with antimalarial activity, and compositions and kits comprising at least one of them. Another aspect of the invention relates to methods for the treatment or prevention or both of malaria comprising administering to a subject a therapeutically effective amount of such a compound. Importantly, a number of the compounds show excellent potency against both chloroquine-sensitive and chloroquine-resistant strains.

  本发明的一个方面涉及具有抗疟活性的替代喹啉，以及包含至少其中之一的组合物和试剂盒。另一个方面涉及用这种化合物向受试者施用治疗有效量的方法，以治疗或预防疟疾。重要的是，其中一些化合物对氯喹敏感和氯喹耐药菌株都表现出极高的效力。
• Synthesis And Use Of Fluorophore-Tagged Antimalarials
  申请人：Lear Martin James

  公开号：US20120100555A1

  公开（公告）日：2012-04-26

  This invention includes a fluorophore-tagged antimalarial represented by the following structural formula (1) or a salt thereof. This invention relates to the synthesis of fluorophore-tagged antimalarials and describes the synthesis of a fluorophore-tagged antimalarial. These fluorophore-tagged antimalarials can be used to image live cells to determine the location of the antimalarial in the cell, identify drug resistance and growth related pathways in Plasmodium isolates, identify new drug targets and chemo-sensitizers to reverse drug resistance.
• Methods of Facilitating Neural Cell Survival Using GDNF Family Ligand (GFL) Mimetics or RET Signaling Pathway Activators
  申请人：Saarma Mart

  公开号：US20130030180A1

  公开（公告）日：2013-01-31

  Disclosed are compounds and methods for treating neurological and other disorders by administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for GFRα receptor molecules, which can be mimetics of glial-derived neurotrophic factor (GDNF) family ligands (GFLs), GFRα/RET signaling pathway agonists, and/or direct RET agonists (activators).
• US8901129B2
  申请人：——

  公开号：US8901129B2

  公开（公告）日：2014-12-02