4-(9-氯-9,10-二氢-10-苯基-9-吖啶)-n,n-二甲基-苯胺盐酸盐 | 77769-31-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-(9-氯-9,10-二氢-10-苯基-9-吖啶)-n,n-二甲基-苯胺盐酸盐
• 英文名称: N,N-Diethyl-4-(9-chloro-9,10-dihydro-10-phenyl-9-acridinyl)aniline
• 英文别名: 4-(9-chloro-10-phenylacridin-9-yl)-N,N-diethylaniline
• CAS: 77769-31-4
• 化学式: C₂₉H₂₇ClN₂
• 分子量: 439.0
• InChiKey: VSDSLMUSMFOWGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  9(p-Diethylaminophenyl)-9-methoxy-10-phenylacridan 、 盐酸 在 盐酸 、 四氢呋喃 作用下， 以 四氢呋喃 为溶剂， 以to give 11.6 g (95.8% yield) of 9(p-diethylaminophenyl)-9-chloro-10-phenylacridan的产率得到4-(9-氯-9,10-二氢-10-苯基-9-吖啶)-n,n-二甲基-苯胺盐酸盐
  参考文献：
  名称：

  9-(P-diethylaminophenyl)-9-chloro-10-phenylacridan agar medium

  摘要：

  化合物9-(对二乙基氨基苯基)-9-氯-10-苯基蒽醌是一种有用的抗菌剂。

  公开号：

  US04263398A1

文献信息

• Enrichment and selective culture of mycobacteria
  申请人：BIOMERIEUX

  公开号：US10597693B2

  公开（公告）日：2020-03-24

  A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4′-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibiting Pseudomonas aeruginosa bacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.

  一种对生物样品中所含分枝杆菌进行富集和选择性培养的工艺，其中将全部或部分样品接种在包括适于分枝杆菌发育和生长的营养成分的培养基中/上、其中培养基作为选择剂至少包括 9-氯-9-(4′-二乙氨基)苯基-9,10-二氢-10-苯基吖啶盐酸盐(或 C-390)和一种能抑制绿脓杆菌的制剂。本发明还涉及一种适用于实施该工艺的培养基，用于分枝杆菌的富集和选择性培养。
• ENRICHISSEMENT ET CULTURE SÉLECTIVE DE MYCOBACTÉRIES
  申请人：bioMérieux

  公开号：EP3253885B1

  公开（公告）日：2019-01-02
• Cavity Induced Allosteric Modification Of Intermolecular Interactions And Methods Of Identifying Compounds That Effect The Same
  申请人：MURALI Ramachandran

  公开号：US20100151507A1

  公开（公告）日：2010-06-17

  Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
• ENRICHMENT AND SELECTIVE CULTURE OF MYCOBACTERIA
  申请人：BIOMERIEUX

  公开号：US20180030500A1

  公开（公告）日：2018-02-01

  A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4′-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibiting Pseudomonas aeruginosa bacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.
• US4263398A
  申请人：——

  公开号：US4263398A

  公开（公告）日：1981-04-21