GR-135402 | 204199-15-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: GR-135402
• 英文别名: Antibiotic GR135402；(1R,2S,4R,5R,8R,9S,11S)-9-formyl-2-[[(2R,3S,4S,5R,6R)-3-hydroxy-5-methoxy-6-methyl-4-[(2Z,4E)-2-methylhexa-2,4-dienoyl]oxyoxan-2-yl]oxymethyl]-5-methyl-13-propan-2-yltetracyclo[7.4.0.02,11.04,8]tridec-12-ene-1-carboxylic acid
• CAS: 204199-15-5
• 化学式: C₃₄H₄₈O₉
• 分子量: 600.75
• InChiKey: YJGMLBISALRTRW-OOKLOIGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  43
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  GR-135402 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 24.0h， 生成 (1S,2S,4R,5R,8R,9S,11S)-2-[[(2R,3S,4S,5R,6R)-3-hydroxy-5-methoxy-6-methyl-4-[(2Z,4E)-2-methylhexa-2,4-dienoyl]oxyoxan-2-yl]oxymethyl]-9-(hydroxymethyl)-5-methyl-13-propan-2-yltetracyclo[7.4.0.02,11.04,8]tridec-12-ene-1-carboxylic acid
  参考文献：
  名称：

  Novel Inhibitors of Fungal Protein Synthesis Produced by a Strain of Graphium putredinis Isolation, Characterisation and Biological Properties.

  摘要：

  The isolation and structure determination of 6 analogues of the fungal protein synthesis inhibitor GR135402, from Graphium putredinis, is described. The relative potencies of the compounds as protein synthesis inhibitors and as in vitro antifungal agents provide interesting insights into the structure-activity relationships in this series.

  DOI：

  10.7164/antibiotics.51.1012

文献信息

• Novel Inhibitors of Fungal Protein Synthesis Produced by a Strain of Graphium putredinis Isolation, Characterisation and Biological Properties.
  作者：TRACY C. KENNEDY、GRAHAM WEBB、RICHARD J. P. CANNELL、OONAGH S. KINSMAN、ROBERT F. MIDDLETON、PHILIP J. SIDEBOTTOM、NICHOLAS L. TAYLOR、MICHAEL J. DAWSON、ANTONY D. BUSS

  DOI：10.7164/antibiotics.51.1012

  日期：——

  The isolation and structure determination of 6 analogues of the fungal protein synthesis inhibitor GR135402, from Graphium putredinis, is described. The relative potencies of the compounds as protein synthesis inhibitors and as in vitro antifungal agents provide interesting insights into the structure-activity relationships in this series.