indazolo[3,2-a]isoquinolin-6-amine | 1452824-31-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: indazolo[3,2-a]isoquinolin-6-amine
• 英文别名: Indazolo[3,2-a]isoquinolin-6-amine
• CAS: 1452824-31-5
• 化学式: C₁₅H₁₁N₃
• 分子量: 233.272
• InChiKey: WWALJEVHFHPBDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(2-nitrophenyl)isoquinolin-3-amine 在 亚磷酸三乙酯 作用下， 反应 0.33h， 以91%的产率得到indazolo[3,2-a]isoquinolin-6-amine
  参考文献：
  名称：

  A straightforward synthesis of indazolo[3,2-a]isoquinolin-6-amines

  摘要：

  4-Substituted 1-bromoisoquinolin-3-amines were subjected to Suzuki coupling with o-nitrophenylboronic acid to yield 1-(2-nitrophenyl) isoquinolinamines, which participated in Cadogan cyclization with triethyl phosphite under microwave irradiation in a sealed vial to yield fluorescent indazolo[3,2-a]isoquinolin-6-amines. The new compounds were also functionalized by transformation of the amino group. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.106

文献信息

• A straightforward synthesis of indazolo[3,2-a]isoquinolin-6-amines
  作者：József Balog、Zsuzsanna Riedl、György Hajós

  DOI：10.1016/j.tetlet.2013.07.106

  日期：2013.9

  4-Substituted 1-bromoisoquinolin-3-amines were subjected to Suzuki coupling with o-nitrophenylboronic acid to yield 1-(2-nitrophenyl) isoquinolinamines, which participated in Cadogan cyclization with triethyl phosphite under microwave irradiation in a sealed vial to yield fluorescent indazolo[3,2-a]isoquinolin-6-amines. The new compounds were also functionalized by transformation of the amino group. (C) 2013 Elsevier Ltd. All rights reserved.