4-[2-amino-6[[2-hydroxy-1(R)-phenylethyl]amino]-4-pyrimidinyl]-N-[2-[4-(aminomethyl)-1-piperidinyl]-3-fluorophenyl]-1H-imidazole-2-carboxamide | 1350917-21-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4-[2-amino-6[[2-hydroxy-1(R)-phenylethyl]amino]-4-pyrimidinyl]-N-[2-[4-(aminomethyl)-1-piperidinyl]-3-fluorophenyl]-1H-imidazole-2-carboxamide
• 英文别名: 5-[2-amino-6-[[(1R)-2-hydroxy-1-phenylethyl]amino]pyrimidin-4-yl]-N-[2-[4-(aminomethyl)piperidin-1-yl]-3-fluorophenyl]-1H-imidazole-2-carboxamide
• CAS: 1350917-21-3
• 化学式: C₂₈H₃₂FN₉O₂
• 分子量: 545.62
• InChiKey: RUYTVHCUBCCDRH-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  171
• 氢给体数：
  6
• 氢受体数：
  10

文献信息

• N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1
  申请人：Tsui Hon-Chung

  公开号：US20130079326A1

  公开（公告）日：2013-03-28

  The present invention provide Imidazole Carboxamide Compounds of Formula (I): wherein D, T, R 1 , R 2 , R 3 , and R 6 are as defined herein, and pharmaceutically acceptable salts of such Imidazole Carboxamide Compounds. The Imidazole Carboxamide Compounds are useful in the treatment of cancer and other aberrant conditions that result from overstimulation of the PDK-1 signaling pathway.

  本发明提供了式(I)的咪唑羧酰胺化合物，其中D、T、R1、R2、R3和R6如本文所定义，并且这些咪唑羧酰胺化合物的药学上可接受的盐。这些咪唑羧酰胺化合物对于治疗癌症和由PDK-1信号通路过度刺激引起的其他异常情况非常有用。
• US8623857B2
  申请人：——

  公开号：US8623857B2

  公开（公告）日：2014-01-07
• [EN] N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1<br/>[FR] INHIBITEURS N-PHÉNYLIMIDAZOLECARBOXAMIDES DE LA PROTÉINE KINASE 3-PHOSPHOINOSITIDE-DÉPENDANTE DE TYPE 1
  申请人：SCHERING CORP

  公开号：WO2011149874A2

  公开（公告）日：2011-12-01

  The present invention provides Imidazole Carboxamide Compounds of Formula (I): wherein D, T, R1, R2, R3, and R6 are as defined herein, and pharmaceutically acceptable salts of such Imidazole Carboxamide Compounds. The Imidazole Carboxamide Compounds are useful in the treatment of cancer and other aberrant conditions that result from overstimulation of the PDK-1 signaling pathway.