Thiopyrano[2,3-b]quinolin-2-one | 1235162-95-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Thiopyrano[2,3-b]quinolin-2-one
• CAS: 1235162-95-4
• 化学式: C₁₂H₇NOS
• 分子量: 213.26
• InChiKey: GPPLGXBJDUWEQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  55.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-formyl-2-mercaptoquinoline 、 乙酰氯 在 sodium methylate 作用下， 以92%的产率得到Thiopyrano[2,3-b]quinolin-2-one
  参考文献：
  名称：

  2-Thieno/Selenopyrano[2,3-b]quinolines: Microwave-Induced One-Pot Synthesis, DNA Binding, and Photocleavage Studies

  摘要：

  We have characterized a new class of 2-thieno/2-selenopyrano[2,3-b]quinolin-2-ol (2c/3c) intercalators exhibiting a novel type of DNA binding and photocleavage activity. The dynamic behavior of these compounds with DNA was investigated by absorption spectra (obtained K-b constant for 2c is 3.6 x 10(6) and for 3c is 2.8 x 10(5)), viscosity, and thermal denaturation studies. Intrinsic binding constants (K-b) have been estimated under a similar set of experimental conditions. An absorption spectral study shows the strong interaction between synthesized 2c, 3c, and base pairs CT-DNA. In addition, the effects of these compounds on DNA cleavage were investigated by photoirradiation at 360 nm and show that the hybrids effectively cleaved double-stranded DNA with UV light of a long wavelength and without any additive.

  DOI：

  10.1080/10426500802529622

文献信息

• 2-Thieno/Selenopyrano[2,3-<i>b</i>]quinolines: Microwave-Induced One-Pot Synthesis, DNA Binding, and Photocleavage Studies
  作者：H. R. Prakash Naik、H. S. Bhojya Naik、T. R. Ravikumar Naik、T. Aravinda、D. S. Lamani、H. Raja Naika

  DOI：10.1080/10426500802529622

  日期：2009.10.13

  We have characterized a new class of 2-thieno/2-selenopyrano[2,3-b]quinolin-2-ol (2c/3c) intercalators exhibiting a novel type of DNA binding and photocleavage activity. The dynamic behavior of these compounds with DNA was investigated by absorption spectra (obtained K-b constant for 2c is 3.6 x 10(6) and for 3c is 2.8 x 10(5)), viscosity, and thermal denaturation studies. Intrinsic binding constants (K-b) have been estimated under a similar set of experimental conditions. An absorption spectral study shows the strong interaction between synthesized 2c, 3c, and base pairs CT-DNA. In addition, the effects of these compounds on DNA cleavage were investigated by photoirradiation at 360 nm and show that the hybrids effectively cleaved double-stranded DNA with UV light of a long wavelength and without any additive.