Cylindrochlorin | 23887-67-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cylindrochlorin
• 英文别名: 8',9'-dehydroascochlorin；ilicicolin E；5-chloro-2,4-dihydroxy-6-methyl-3-[(2E,4E)-3-methyl-5-[(1S,2R,6R)-1,2,6-trimethyl-5-oxocyclohex-3-en-1-yl]penta-2,4-dienyl]benzaldehyde
• CAS: 23887-67-4
• 化学式: C₂₃H₂₇ClO₄
• 分子量: 402.918
• InChiKey: ZLAQYJKDQSZARB-FLDGXQSCSA-N

物化性质

• 沸点：
  561.7±50.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Cylindrochlorin 在 palladium on activated charcoal 氢氧化钾 、 氢气 作用下， 反应 0.08h， 以64.7%的产率得到壳二孢氯素
  参考文献：
  名称：

  A Novel Testosterone 5.ALPHA.-Reductase Inhibitor, 8',9'-Dehydroascochlorin Produced by Verticillium sp. FO-2787.

  摘要：

  从培养的黄萎病菌菌丝体中分离出一种新的睾酮 5α-还原酶抑制剂，8'9'-脱氢壳二氯素。 FO-2787。该化合物（分子量：402，C23H27ClO4）由 5-氯醛和 2,3,4-三甲基环己烯酮部分组成，它们通过 (2E,4E)-3-甲基-2,4-戊二烯链连接。从大鼠前列腺制备的新型微生物代谢物对睾酮5α-还原酶活性的IC50值为4×10-4M。

  DOI：

  10.1248/cpb.42.953

文献信息

• NOVEL TRANSCRIPTIONAL FACTOR, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
  申请人：NRL Pharma, Inc.

  公开号：EP1616856B1

  公开（公告）日：2011-06-22
• MEROTERPENOID COMPOUNDS FOR USE IN THE PREVENTION AND TREATMENT OF A NEUROLOGICAL DISORDER
  申请人：Société des Produits Nestlé S.A.

  公开号：EP3681488A1

  公开（公告）日：2020-07-22
• TARGETED TREATMENT OF AUTISM SPECTRUM DISORDER AND OTHER NEUROLOGICAL OR PSYCHIATRIC DISORDERS
  申请人：Tufts Medical Center, Inc.

  公开号：US20210228531A1

  公开（公告）日：2021-07-29

  Disclosed are methods of treating autism spectrum disorder (ASD) by administering a therapeutically effective amount of an isoprenoid antibiotic to subjects identified with a splicing defect in an ASD associated gene. The method of treating a subject with a neurological disease is carried out by identifying the subject comprising a splicing defect in an autism spectrum disorder (ASD)-associated gene, the target gene being characterized as having an hnRNP L binding site. The subject is treated by administering a spliceopathy rescue agent to repair the splicing defect. Also disclosed are methods of upregulating hnRNP L and hnRNP L targets by administering a therapeutically effective amount of an isoprenoid antibiotic. Methods of screening compounds for use in treating autism spectrum disorder (ASD) are also described.
• COMPOUNDS AND METHODS FOR THE TREATMENT OF AUTISM SPECTRUM DISORDER AND OTHER NEUROLOGICAL OR PSYCHIATRIC DISORDERS
  申请人：Tufts Medical Center, Inc.

  公开号：US20210236438A1

  公开（公告）日：2021-08-05

  Disclosed are methods of treating autism spectrum disorder (ASD) by administering a therapeutically effective amount of an isoprenoid antibiotic. Also disclosed are methods of modulating (either upregulation or downregulation) hnRNP L and hnRNP L targets by administering a therapeutically effective amount of an isoprenoid antibiotic. Methods of screening compounds for use in treating autism spectrum disorder (ASD) are also described.
• US7629471B2
  申请人：——

  公开号：US7629471B2

  公开（公告）日：2009-12-08