trans(3,4)-3-Hydroxymethyl-4-(1',2'-dihydroxy-ethyl)-cyclopentanol-(1) | 92334-74-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: trans(3,4)-3-Hydroxymethyl-4-(1',2'-dihydroxy-ethyl)-cyclopentanol-(1)
• 英文别名: 1-[(1S,2S)-4-hydroxy-2-(hydroxymethyl)cyclopentyl]ethane-1,2-diol
• CAS: 92334-74-2
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: PVKBMMUPKBSSGK-RRABCLCVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  trans(3,4)-3-Hydroxymethyl-4-(1',2'-dihydroxy-ethyl)-cyclopentanol-(1) 在 过碘酸 作用下， 生成 3-Formyl-4-hydroxymethyl-cyclopentanol-(1)
  参考文献：
  名称：

  Zur Biosynthese von Brefeldin A

  摘要：

  AbstractBy feeding growing cultures of Penicillium brefeldianum Dodge with [‐14C]‐acetate radioactive brefeldin A (C16H24O4) was obtained. By extensive degradation of [14C]‐brefeldin A, the individual radioactivity of 12 of the 16 carbon atoms was determined quantitatively. The pattern of the distribution of the radioactivity shows that 8 acetate units have been incorporated into the metabolite in a regular manner. These findings suggest an octaketide as an intermediate. Possible mechanisms for the formation of the trans‐fused cyclopentane ring are discussed.

  DOI：

  10.1002/hlca.19680510815