((1S,2R,5R)-2-Aminomethyl-6,6-dimethyl-bicyclo[3.1.0]hex-2-yl)-acetic acid | 473829-51-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ((1S,2R,5R)-2-Aminomethyl-6,6-dimethyl-bicyclo[3.1.0]hex-2-yl)-acetic acid
• 英文别名: 2-[(1S,2R,5R)-2-(aminomethyl)-6,6-dimethyl-2-bicyclo[3.1.0]hexanyl]acetic acid
• CAS: 473829-51-5
• 化学式: C₁₁H₁₉NO₂
• 分子量: 197.277
• InChiKey: QDAFOWRBCRPETR-HDBBIHSSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Fused bicyclic or tricyclic amino acids
  申请人：Pfizer Inc.

  公开号：US20030078300A1

  公开（公告）日：2003-04-24

  The compounds of the instant invention are bicyclic or tricyclic amino acids useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, sleep disorders, visceral pain disorders, and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.

  本发明的化合物是双环或三环氨基酸，在治疗癫痫、晕厥发作、运动减少、头颅疾病、神经退行性疾病、抑郁症、焦虑、恐慌、疼痛、关节炎、神经病理性疾病、睡眠障碍、内脏疼痛疾病和胃肠疾病方面具有用处。包括用于制备最终产品和在过程中有用的中间体的方法。还包括含有一种或多种这些化合物的药物组合物。
• [EN] FUSED BICYCLIC OR TRICYCLIC AMINO ACIDS<br/>[FR] ACIDES AMNINES BICYCLIQUES OU TRICYCLIQUES FONDUS
  申请人：WARNER LAMBERT CO

  公开号：WO2002085839A1

  公开（公告）日：2002-10-31

  The compounds of the instant invention are bicyclic or tricyclic amino acids useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, arthritis, neuropathological disorders, sleep disorders, visceral pain disorders, and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included.

  本发明的化合物是双环或三环氨基酸，可用于治疗癫痫、晕厥发作、低动力症、颅内疾病、神经退行性疾病、抑郁症、焦虑症、惊恐症、疼痛、关节炎、神经病理学疾病、睡眠障碍、内脏疼痛疾病和胃肠疾病的治疗。本发明还包括用于制备最终产品和在过程中有用的中间体的方法。还包括含有一个或多个化合物的制药组合物。
• Therapeutic use of fused bicyclic or tricyclic amino acids
  申请人：——

  公开号：US20040092591A1

  公开（公告）日：2004-05-13

  The compounds of the instant invention are bicyclic or tricyclic amino acids useful in the treatment of fibromylagia. Pharmaceutical compositions containing one or more of the compounds for use in the treatment of fibromyalgia are also included.

  本发明的化合物是二环或三环氨基酸，可用于治疗纤维肌痛。还包括含有一种或多种该化合物的制药组合物，用于治疗纤维肌痛。
• Liquid pharmaceutical compositions
  申请人：——

  公开号：US20020198261A1

  公开（公告）日：2002-12-26

  A liquid pharmaceutical composition of a GABA analog comprising at least one polyhydric alcohol containing 2 to 6 carbon atoms having a pH of about 5.5 to about 7.0 and additionally a two-component liquid pharmaceutical composition comprising a first component comprising a powder mixture comprising a GABA analog and a solid polyhydric alcohol, and a second component comprising a liquid base are described, as well as methods to prepare the compositions and a method for treating cerebral diseases, including epilepsy, faintness attacks, hypokinesia and cranial traumas, neurodegenerative disorders, depression, mania and bipolar disorders, anxiety, panic, inflammation, renal colic, insomnia, gastrointestinal damage, incontinence, pain, including neuropathic pain, muscular pain, skeletal pain, and migraine using a therapeutically effective amount of the pharmaceutical compositions.

  本发明描述了一种 GABA 类似物的液体药物组合物，该类似物包含至少一种含有 2 至 6 个碳原子的多元醇，其 pH 值约为 5.5 至 7.0，另外还描述了一种双组分液体药物组合物，其第一组分包括由 GABA 类似物和固体多羟基乙醇组成的粉末混合物，第二组分包括液体基质，还描述了制备组合物的方法和治疗脑部疾病（包括癫痫）的方法、昏厥发作、运动机能减退和颅脑创伤、神经退行性疾病、抑郁症、躁狂症和双相情感障碍、焦虑症、恐慌症、炎症、肾绞痛、失眠、胃肠道损伤、大小便失禁、疼痛（包括神经病理性疼痛、肌肉疼痛、骨骼疼痛和偏头痛）等。
• FUSED BICYCLIC OR TRICYCLIC AMINO ACIDS
  申请人：Warner-Lambert Company LLC

  公开号：EP1379494A1

  公开（公告）日：2004-01-14