(5R)-3-(2-bicyclo[2.2.1]heptanyl)-5-[[5-(trifluoromethyl)pyridin-2-yl]oxymethyl]-1,3-oxazolidin-2-one | 1068004-50-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (5R)-3-(2-bicyclo[2.2.1]heptanyl)-5-[[5-(trifluoromethyl)pyridin-2-yl]oxymethyl]-1,3-oxazolidin-2-one
• CAS: 1068004-50-1
• 化学式: C₁₇H₁₉F₃N₂O₃
• 分子量: 356.345
• InChiKey: OHVVHJGJZFITQL-NYFJODQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  51.7
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11 -HYDROXYSTEROID DEHYDROGENASE TYPE I
  申请人：Institute Of Medicinal Molecular Design, Inc.

  公开号：EP2141154A1

  公开（公告）日：2010-01-06

  Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein R1 is optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycle or optionally substituted heterocyclealkyl, X is -O-, -NR3-, -NR3 C(=O)- or -NR3 S(=O)2-, R2 is optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, R3 is hydrogen or optionally substituted alkyl.

  本发明公开了一种可用作 11β- 羟基类固醇脱氢酶 1 型抑制剂的化合物。 一种由式表示的化合物： 、其药学上可接受的盐或其溶液、 其中 R1 是任选取代的环烷基、任选取代的环烷基烷基、任选取代的杂环或任选取代的杂环烷基、 X 是-O-、-NR3-、-NR3 C(=O)- 或 -NR3 S(=O)2-、 R2 是任选取代的芳基、任选取代的芳烷基、任选取代的杂芳基或任选取代的杂芳基烷基、 R3 是氢或任选取代的烷基。
• OXAZOLIDINONE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
  申请人：Itai Akiko

  公开号：US20100113448A1

  公开（公告）日：2010-05-06

  Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein R 1 is optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocycle or optionally substituted heterocyclealkyl, X is —O—, —NR 3 —, —NR 3 C(═O)— or —NR 3 S(═O) 2 —, R 2 is optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, R 3 is hydrogen or optionally substituted alkyl.
• US7998992B2
  申请人：——

  公开号：US7998992B2

  公开（公告）日：2011-08-16