6-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-5-hydroxymethyl-2,2,4-trimethylquinoline | 179898-56-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-5-hydroxymethyl-2,2,4-trimethylquinoline
• 英文别名: 4-chloro-2-[5-(hydroxymethyl)-2,2,4-trimethyl-1H-quinolin-6-yl]phenol
• CAS: 179898-56-7
• 化学式: C₁₉H₂₀ClNO₂
• 分子量: 329.826
• InChiKey: RAFXJLWGZUXTAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(5-chloro-2-hydroxyphenyl)-1,2-dihydro-5-hydroxymethyl-2,2,4-trimethylquinoline 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 水 、 乙酸乙酯 、 1,2-二氯乙烷 为溶剂， 以10 mg (53%)的产率得到9-Chloro-1,2-dihydro-2,2,4-trimethyl-5H-chromeno[3,4-f]quinoline
  参考文献：
  名称：

  Steroid receptor modulator compounds and methods

  摘要：

  披露了对类固醇受体具有高亲和力、高选择性调节剂的非类固醇化合物。还披露了包含这些化合物的药物组合物、使用所披露的化合物和组合物治疗需要类固醇受体激动剂或拮抗剂治疗的患者的方法，以及在制备这些化合物中有用的中间体和制备类固醇受体调节剂化合物的过程。

  公开号：

  US05696127A1

文献信息

• Novel 1-2-Dihydroquinoline Derivative Having Glucocorticoid Receptor Binding Activity
  申请人：Matsuda Mamoru

  公开号：US20090326009A1

  公开（公告）日：2009-12-31

  An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R 1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R 2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R 3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R 4 and R 5 represent a hydrogen atom or the like; R 6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R 7 represents OR 8 , NR 8 R 9 , SR 8 , S(O)R 8 or S(O) 2 R 8 , wherein R 8 represents an aryl group, a heterocyclic group or the like and R 9 represents a hydrogen atom or the like.

  本发明的目的是研究合成一种新型1,2-二氢喹啉衍生物，并发现该衍生物的药理作用。通式（1）表示的化合物或其盐在治疗糖皮质激素受体相关疾病方面具有有效性。在该式中，环X表示苯环或吡啶环；R1表示卤素原子、烷基、羟基、烷氧基、氨基或类似物；p表示0至5的整数；R2表示卤素原子、烷基、羟基或类似物；q表示0至2的整数；R3表示氢原子、烷基、烯基或类似物；R4和R5表示氢原子或类似物；R6表示氢原子或类似物；A表示烷基链或类似物；R7表示OR8、NR8R9、SR8、S（O）R8或S（O）2R8，其中R8表示芳基、杂环基或类似物，R9表示氢原子或类似物。
• Method for preventing or treating a glucocorticoid receptor-related disease
  申请人：Matsuda Mamoru

  公开号：US20110263589A1

  公开（公告）日：2011-10-27

  A method of preventing or treating a glucocorticoid receptor-related disease involving administering a therapeutically effective amount of a 1,2-dihydroquinoline compound or a pharmaceutically acceptable salt thereof.

  一种预防或治疗与糖皮质激素受体相关的疾病的方法，包括给予治疗有效量的1,2-二氢喹啉化合物或其药学上可接受的盐。
• Methods for the preparation of coumarine derivatives
  申请人：LIGAND PHARMACEUTICALS INCORPORATED

  公开号：EP1041071A1

  公开（公告）日：2000-10-04

  Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.

  本发明公开了对类固醇受体具有高亲和力、高选择性调节作用的非类固醇化合物。还公开了含有此类化合物的药物组合物、使用所公开化合物和组合物治疗需要类固醇受体激动剂或拮抗剂治疗的患者的方法、制备化合物时有用的中间体以及制备类固醇受体调节剂化合物的工艺。
• NOVEL 1-2-DIHYDROQUINOLINE DERIVATIVE HAVING GLUCOCORTICOID RECEPTOR BINDING ACTIVITY
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP1944290A1

  公开（公告）日：2008-07-16

  An object of the present invention is to study synthesis of a novel 1,2-dihydroquinoline derivative and to find a pharmacological action of the derivative. A compound represented by the general formula (1) or a salt thereof is effective in the treatment of a glucocorticoid receptor-related disease. In the formula, the ring X represents a benzene ring or a pyridine ring; R1 represents a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, an amino group or the like; p represents an integer of 0 to 5; R2 represents a halogen atom, an alkyl group, a hydroxy group or the like; q represents an integer of 0 to 2; R3 represents a hydrogen atom, an alkyl group, an alkenyl group or the like; R4 and R5 represent a hydrogen atom or the like; R6 represents a hydrogen atom or the like; A represents an alkylene group or the like; and R7 represents OR8, NR8R9, SR8, S (O) R8 or S (O)2R8, wherein R8 represents an aryl group, a heterocyclic group or the like and R9 represents a hydrogen atom or the like.

  本发明的目的是研究一种新型 1,2-二氢喹啉衍生物的合成，并找到该衍生物的药理作用。通式（1）代表的化合物或其盐可有效治疗糖皮质激素受体相关疾病。式中，环 X 代表苯环或吡啶环；R1 代表卤素原子、烷基、羟基、烷氧基、氨基或类似基团；p 代表 0 至 5 的整数；R2 代表卤素原子、烷基、羟基或类似基团；q 代表 0 至 2 的整数；R3 代表氢原子、烷基、烯基或类似物； R4 和 R5 代表氢原子或类似物； R6 代表氢原子或类似物； A 代表亚烷基或类似物；以及 R7 代表 OR8、NR8R9、SR8、S (O) R8 或 S (O)2R8 其中 R8 代表芳基、杂环基或类似物，R9 代表氢原子或类似物。
• STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS
  申请人：LIGAND PHARMACEUTICALS, INC.

  公开号：EP0800519A1

  公开（公告）日：1997-10-15